Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1976-10-26
1978-07-04
Padgett, Benjamin R.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
23230B, 424 12, G01N 3316, A61K 4300
Patent
active
040988767
ABSTRACT:
Method of determining the presence and/or concentration of a polyvalent antigenic substance in a fluid. The method comprises the steps of incubating the fluid with labeled antibodies to the substance to form a first labeled immunochemical complex and then incubating that complex with immobilized antibodies to the substance to form a second labeled complex which is separated from the incubation medium. The amount of label in the second complex provides a means for detecting and/or quantitating the substance in the fluid. By reversing the sequence of incubation steps in a "two-site" or sandwich assay, greater sensitivity is achieved and an intermediate washing step is eliminated.
REFERENCES:
patent: 3850752 (1974-11-01), Schuurs et al.
patent: 3896217 (1975-07-01), Johnson
patent: 3975511 (1976-08-01), Vann et al.
patent: 3995019 (1976-11-01), Jerome
Piasio Roger N.
Ryan James W.
Woiszwillo James E.
Corning Glass Works
Janes Jr. Clinton S.
Maycock William E.
Nucker Christine M.
Padgett Benjamin R.
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