Reverse isotope dilution assay and lactose intolerance assay

Details Reverse isotope dilution assay and lactose intolerance assay Reverse isotope dilution assay and lactose intolerance assay

2005-06-07

2005-06-07

Jones, Dameron L. (Department: 1616)

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

C424S001110, C424S001650, C424S009100, C424S009200, C424S001730

Reexamination Certificate

active

06902719

ABSTRACT:
A “reverse isotope dilution assay” herein, wherein a pathway that produces a given metabolite is assayed by diluting a labelled metabolite produced by a second constitutive pathway. In one aspect, the invention relates to a method for monitoring lactose maldigestion or lactose intolerance in humans. Specifically, the method requires administering a reverse tracer of labeled glucose and unlabeled lactose to an individual and assessing labeled carbon dioxide in breath or blood. If the lactose is digested, the labeled CO2produced by the labeled glucose is diluted by the metabolism of the lactose.

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