Reversal of multi-drug resistance by triphenyl-azacycloalkane de

Details Reversal of multi-drug resistance by triphenyl-azacycloalkane de Reversal of multi-drug resistance by triphenyl-azacycloalkane de

1996-01-04

1997-09-23

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A01K 31445

Patent

active

056705212

ABSTRACT:
Certain triphenylpiperidines reverse drug resistance in multi-drug resistant tumors. These compounds apparently function by inhibiting a p-glycoprotein pump which becomes activated in late stage tumor development and which is inherently present in tumors from certain origins.

REFERENCES:
patent: 2898339 (1959-08-01), Wheeler et al.
patent: 3956296 (1976-05-01), Duncan et al.
patent: 4035372 (1977-07-01), Deason et al.
patent: 4851423 (1989-07-01), Girijavallab-han et al.
patent: 4990511 (1991-02-01), Nakajima et al.
Kartner et al, Scientific American, pp. 44-51, Mar. 1989.
Tsuruo, et al, Cancer Research, 43, pp. 2905-2910, Jun. 1983.
Helson, Cancer Drug Delivery, vol. 1, No. 4, pp. 353-361, (1984).
Tsuruo et al, Cancer Research, 43, pp. 2267-2272, May 1983.
Gottesman et al, TIPS vol. 9, pp. 54-58, Feb. 1988.
Fields et al, Nature, vol. 333, pp. 278-280, (1988).
Chemical Abstracts, vol. 102:45760p, (1985).
Liu-Hong et al, Yaoxue Xuebao, 19(9) pp. 671-675, 198.
Chemical Abstracts vol. 102, No. 2490f Xuebao, 1984, pp. 171-175, "Piperthy 4-(2,2-dipheriylethyl)-1-(phenylmethal)-, hydrochloride".
Endicott et al, Annu. Rev. Biochem. vol. 58, 1989, pp. 137-171 "The Bio-chemistry of P-glycoprotein-mediated Multidrug Resistance".
Ford, Pharmacological Reviews, vol. 42, No. 3, 1990, pp. 155-199, "Pharmacology of drugs that alter multidrug resistance in cancer".
Wu, et al, Cancer Research, 52, pp. 3029-3034, Jun. 1, 1992.
Chemical Abstracts, vol. 67,32621c, 1967.

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