Reversal of multi-drug resistance by tetraarylethylenes

Details Reversal of multi-drug resistance by tetraarylethylenes Reversal of multi-drug resistance by tetraarylethylenes

1994-12-15

1996-06-04

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31435

Patent

active

055233040

ABSTRACT:
Certain tetraarylethylenes reverse drug resistance in multi-drug resistant tumors. These compounds apparently function by inhibiting a p-glycoprotein pump which becomes activated in late stage tumor development and which is inherently present in tumors from certain origins.

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Tsuruo et al., Cancer Research 43, pp. 2905-2910 (1983).
Helson, Cancer Drug Delivery vol. 1, No. 4, pp. 353-361 (1984).
Tsuruo et al., Cancer Research 43, pp. 2267-2272 (1983).
Gottesman et al., TIPS Reviews vol. 9,--54-58 (1988).
Fields et al., Nature vol. 333, pp. 278-280 (1988).

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