Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1995-12-06
1997-09-09
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
A61K 31135
Patent
active
056657803
ABSTRACT:
Certain tetraarylethylenes reverse drug resistance in multi-drug resistant tumors. These compounds apparently function by inhibiting a p-glycoprotein pump which becomes activated in late stage tumor development and which is inherently present in tumors from certain origins.
REFERENCES:
Kartner et al., Scientific American, pp. 44-51, Mar. 1989.
Tsuruo et al, Cancer Research, 43, pp. 2905-2910, Jun. 1993.
Helson, Cancer Drug Delivery, vol. 1, pp. 353-361, Nov. 4, 1984.
Tsuruo et al, Cancer Research, 43, pp. 2267-2272, May 1983.
Gottesman et al, TIPS Reviews, vol. 9, pp. 54-58, Feb. 1988.
Fields et al, Nature, vol. 333, pp. 278-280, May 1988.
Richardson et al, Journal of Medicinal Chemistry, vol. 18, No. 7, pp. 689-691, 1975.
Endicott et al, Annu. Rev. Biochem. 58:137-171, 1989.
Boudreaux William R.
Goldberg Jerome D.
Merrell Pharmaceuticals Inc.
LandOfFree
Reversal of multi-drug resistance by tetraarylethylenes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Reversal of multi-drug resistance by tetraarylethylenes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Reversal of multi-drug resistance by tetraarylethylenes will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-70724