Reusable solid support for oligonucleotide synthesis

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C536S025330, C536S025340

Reexamination Certificate

active

07135564

ABSTRACT:
A reusable linker arm for solid support oligonucleotide synthesis, the linker arm comprising formula (a) wherein Z is a linker moiety and T is an organic radical. A method for adding one or more nucleosides on the linker arm is also described

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Pon et al. (III), “Hydroquinone-O,O′-Diacetic Acid as a More Labile Replacement for Succinic Acid Linkers in Solid-Phase Oligonucleotide Synthesis,”Tetrahedron Letters, 38(19), 3327-3330 (May 12, 1997).
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Pon et al. (V), “Hydroquinone-O, O′-Diacetic Acid (‘Q-Linker’) as a Replacement for Succinyl and Oxalyl Linker Arms in Solid Phase Oligonucleotide Synthesis,”Nucleic Acids Research, 25(18), 3629-3635 (1997).
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