Retrovirus detection method

Details Retrovirus detection method Retrovirus detection method

1996-03-22

1998-05-05

Smith, Lynette F.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 71, 435 72, C12Q 170, G01N 3353, G01N 33567

Patent

active

057472432

ABSTRACT:
A method, and groups of cells and retroviruses useful in the performance of the method, for testing for the presence or amount of a first retrovirus in a specimen is disclosed. A replication defective retroviral construct having a marker sequence is exposed to the specimen and the presence or amount of a recombinant retrovirus carrying the marker sequence is determined. The replication defective vector may be disposed in cells, with the specimen being tested for the presence or amount of a retrovirus, or it may be disposed in a retrovirus, with the specimen being a group of cells which are tested for the presence or amount of a first retrovirus. In either case, where a first retrovirus complements the defective vector, a recombinant retrovirus carrying the marker sequence will be produced. The first retrovirus to be tested for may be of a previously known, or unknown type, and may be any of a group of retroviruses.

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