Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1990-01-10
1991-11-19
Nucker, Christine
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530350, 530395, 530403, 530826, 435 5, 435974, C07K 1300, C07K 1514, C07K 1504
Patent
active
050667823
ABSTRACT:
The invention relates to a new class of retroviruses, designated by HIV-2, of which samples have been deposited to the ECACC under numbers 87.01.1001 and 87.01.1002 and to the NCIB under numbers 12.398 and 12.399.
It relates also to antigens capable to be obtained from this virus, particularly proteins p12, p16, p26 and gp140. These various antigens can be used for the diagnosis of the disease, especially by contacting these antigens with a serum of a patient submitted to the diagnosis.
It relates to immunogenic compositions containing more particularly the glycoprotein gp140. Finally it concerns nucleotidic sequences, which can be used especially as hydridization probes, derived from the RNA of HIV-2.
REFERENCES:
patent: 4629783 (1986-12-01), Cosand
Clavel et al., "Molecular Cloning and Polymorphism of the Human Immune Deficiency Virus Type 2"; Nature 324 (1986) 691-695.
Wang et al., "Detection of Antibodies to Human T--Lymphotropic Virus Type III by Using a Synthetic Peptide of 21 Amino Acids Residues Corresponding to a Highly Antigenic Segment of gp41 Envelope Protein," Proc. Natl. Acad. Sci U.S.A., 83 (1986) 6159-6163.
Chakrabarti et al, "Sequence of Simian immunodeficiency Virus and Its relationship to other human and Simian retroviruses", Nature 328 (1987) 543-550.
Alizon Marc
Brun-Vezinet Francoise
Chamaret Solange
Clavel Francois
Guetard Denise
Institut Pasteur
Nucker Christine
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