Retroviral vectors with foreign-sequence insertion between...

Details Retroviral vectors with foreign-sequence insertion between... Retroviral vectors with foreign-sequence insertion between...

2006-07-04

2006-07-04

Woitach, Joseph (Department: 1633)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S455000, C435S320100, C435S069100, C435S091400, C514S04400A, C424S093100

Reexamination Certificate

active

07070992

ABSTRACT:
The subject of the invention is retroviral gene transfer vectors in which foreign sequences are introduced between the retroviral primer binding site (PBS) and the retroviral splice donor (SD). The efficiency of gene expression is improved by this modification, and the vectors are characterized by an increased reliability during use.

REFERENCES:
patent: 19822115 (1999-11-01), None
Hirota et al.,, Leukemia, 11 Suppl 3, 102-5, Apr. 1997.
Lodmell (Antisense and Nucleic Acid Drug Development, 8, 6, 517-29, 1998).
Guesdon et al. Virology. 2001, vol. 288, pp. 81-88.
Hildinger et al., “Design of 5′ Untranslated Sequences in Retroviral Vectors Developed for Medical Use,”J. Virol., 73(5) :4083-4089 (1999).

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