Retroviral vectors for expression in embryonic cells

Details Retroviral vectors for expression in embryonic cells Retroviral vectors for expression in embryonic cells

1994-12-21

1998-01-13

Low, Christopher S. F.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4353201, 4352351, 4351723, 435352, 435354, 536 241, 536 231, 424 931, 424 932, 424 9321, 514 44, 935 22, 935 32, 935 66, 935 70, C12N 510, C12N 516, C12N 1586

Patent

active

057078653

ABSTRACT:
Retroviral plasmid vectors which include an enhancer region obtained from a virus selected from the group consisting of Myeloproliferative Sarcoma Virus and polyoma virus, and a primer binding site obtained from murine retrovirus. The retroviral plasmid vector does not include a negative control region. The vector also may include a nucleic acid sequence which encodes demethylation of cytosine residues in the proviral LTR. Such plasmid vectors are especially useful in the generation of retroviral vector particles which may be expressed in embryonic cells, such as embryonic stem cells.

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