Retroviral vectors for delivery of interfering RNA

Details Retroviral vectors for delivery of interfering RNA Retroviral vectors for delivery of interfering RNA

2004-10-21

2009-11-03

Chong, Kimberly (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S024310, C436S006000, C436S169000, C436S169000, C514S04400A

Reexamination Certificate

active

07612195

ABSTRACT:
Provided herein are retroviral vectors for delivering interfering RNA into cells.

REFERENCES:
patent: 5624803 (1997-04-01), Noonberg et al.
patent: 2004/0234504 (2004-11-01), Verma et al.
patent: WO 2004/022722 (2004-03-01), None
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Chang et al. The molecular genetics of Lentiviral vectors—Current and Future Perspectives. Current Gene Therapy 2001, vol. 1: 237-251.
Devroe et al., Retrovirus-delivered siRNA, BMC Technology, Biomed Central, Aug. 28, 2002, pp. 1-5.
Lieberman et al., Interfering with disease: opportunities and roadblocks to harnessing RNA interference, Trends in Molecular Medicine, Sep. 2003, vol. 9, No. 9, pp. 397-403.
Liu et al, Short hairpin RNA and retroviral vector-mediated silencing of p53 in mammalian cells, Biochem. & Biophys. Res. Comm., Oct. 12, 2004, vol. 324, No. 4, pp. 1173-1178.
Mitta et al., Advanced modular self-inactivating lentiviral expression vectors for multigene interventions in mammalian cells and in vivo transuction, Nucleic Acids Research, Nov. 1, 2002, vol. 30, No. 21, pp. E113.1 to E113.18.
Tiscornia et al., A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA, PNAS, vol. 100, No. 4, Feb. 18, 2004, pp. 1844-1848.
Rubinson et al., A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference, Nature Genetics, vol. 33, No. 3, Mar. 2003, pp. 401-406.

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