Retroviral vectors comprising a VL30-derived psi region

Details Retroviral vectors comprising a VL30-derived psi region Retroviral vectors comprising a VL30-derived psi region

1994-09-07

1998-05-05

Guzo, David

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

435357, 435367, 4353201, 536 241, C12N 701, C12N 510, C07H 2104

Patent

active

057473234

ABSTRACT:
The invention proposes a packaging signal (psi) region of at most 400 nucleotides, capable of promoting encapsidation of a retroviral vector, which is substantially homologous to the 5' end of a murine viral-like cellular sequence of type VL30, as well as a retroviral vector comprising said psi region.

REFERENCES:
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patent: 5543328 (1996-08-01), McClelland et al.
"Report and Recommendations of the Panel to Assess the NIH Investment in earch on Gene Therapy", Dec. 7, 1995.
Eliot Marshall, "Zero Hype, More Biology Needed for Gene Therapy", Science, vol. 270, 15 Dec. 1995, p. 1751.
Eliot Marshall, "Gene Therapy's Growing Pains", Science, vol. 269, 25 Aug. 1995, pp. 1050-1055.
Dougherty et al. "New Retroviral Helper Cells with Almost No Nucleotide Sequence Homology to Retrovirus Vectus", J. Virol., Jul. 1989, vol. 63, No. 7, pp. 3209-3212.
Yu et al. "Self-inactivating Retroviral Vectors Designed for Transfer of Whole Genes Into Mammalian Cells", PNAS, vol. 83, pp. 3194-3198, May 1986.
Torrent et al., Symposium on Foetal and Neonatal Cell Transplantation and Retroviral Gene Therapy, Annecz, France, Jan. 5-8, 1992.

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