Retroviral vectors carrying senescent cell derived...

Details Retroviral vectors carrying senescent cell derived... Retroviral vectors carrying senescent cell derived...

2006-07-11

2006-07-11

Wilson, Michael (Department: 1632)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C424S093100, C424S093210, C435S325000

Reexamination Certificate

active

07074398

ABSTRACT:
The present invention relates to retroviral vectors carrying DNA sequences encoding SDI-1, function analogues of SDI-1, or fragments thereof, or antisense SDI-1 DNA sequences, and especially retroviral vectors carrying the SDI-1 or antisense SDI-1 sequences under the transcriptional control of target cell specific regulatory elements or promoters or X-ray inducible promoters. Further, the invention relates to the use of such retroviral vectors for the production of recombinant retroviral particles useful for the treatment of disorders or diseases responsive to the anti-proliferative activity of SDI-1, or the proliferative activity of antisense SDI-1 sequences.

REFERENCES:
patent: 5863904 (1999-01-01), Nabel et al.
patent: WO 93/12251 (1993-06-01), None
patent: WO 94/29437 (1994-12-01), None
patent: WO 95/06415 (1995-03-01), None
patent: WO 95/13375 (1995-05-01), None
patent: WO 96/07748 (1996-03-01), None
patent: WO 9607748 (1996-03-01), None
patent: WO 97/09440 (1996-09-01), None
Feldman et al. Fundamental & Clinical Pharmacology, vol. 9, pp. 8-16, 1995.
Crystal Science, vol. 270, p. 404-410, 1995.
Tsang et al. Vaccine Res., vol. 3, p. 183-193), 1994.
Haertig et al. J. Virology, vol. 67, pp. 813-821, 1993.
Nakanishi et al. EMBO Journal, vol. 14, pp. 555-563, 1995.
Miller et al. Biotechniques, vol. 7, pp. 980-990, 1989.
Price et al. PNAS, USA, vol. 84, pp. 156-160, 1987.
Noda et al. Exp. Cell Res., vol. 211, pp. 90-98, 1994.
Stange et al. Biomat. Art. Cells and Immob. Biotech., vol. 21, pp. 343-352, 1993.
Definition of antisense DNA from Stedman's Medical Dictionary.
Bond, J.A., et al., “Mutant p53 Rescues Human Diploid Cells from Senescence without Inhibiting the Induction of SDI1/WAF1”,Can. Res.,55:2404-2409 (1995).
Katayose, D., et al., “Consequences of p53 Gene Expression by Adenovirus Vector on Cell Cycle Arrest and Apoptosis in Human Aortic Vascular Smooth Muscle Cells”,Biochem. Biophysic. Res. Comm.,215 (2) :446-451 (1995).
Skotzko, M., et al., Retroviral Vector-mediated Gene Transfer of Antisense Cyclin G1 (CYCG1) Inhibits Proliferation of Human Osteogenic Sarcoma Cells,Can. Res.,55:5493-5498 (1995).
Nakanishi, M., et al., “Exit from G0and entry into cell cycle of cells expressing p21Sdi1antisense RNA”,Proc. Natl. Acad. Sci. USA, 92:4352-4356 (1995).
Zakut, R., “The tumor suppression function of p21Wafis contained in it N-terminal half (‘half-WAF’)”,Oncog.,11:393-395 (1995).
Johnson, M., et al., “Evidence for a p53-Independent Pathway for Upregulation of SDI1/CIP1/WAF1/p21 RNA in Human Cells”,Mol. Carcin.,11:59-64 (1994).
Rubelj, I. and Pereira-Smith, O.M., “SV40-Transformed Human Cells in Crisis Exhibit Changes That Occur in Normal Cellular Senescence”,Exper. Cell Res.,211:82-89 (1994).
Harper, J.W., et al., “The p21 Cdk-Interacting Protein Cip1 Is a Potent Inhibitor of G1 Cyclin-Dependent Kinases”,Cell, 75:805-816 (1993).
El-Deiry, W.S., et al., “WAF1, a Potential Mediator of p53 Tumor Suppression”,Cell, 75:817-825 (1993).
Xiong, Y., et al., “p21 is a universal Inhibitor of cyclin kinases”,Nature, 366:701-704 (1993).
Hunter, T., “Braking the Cycle”,Cell, 75:839-841 (1993).
Günzburg, W.H., et al., “A Mammary-Specific Promoter Directs Expression of Growth Hormone not only to the Mammary Gland, but also to Bergman Glia Cells in Transgenic Mice”,Mol. Endocrin.,5(1) :123-133 (1991).
U.S. Appl. No. 08/808,827, Gunzburg et al.
Genbank® Accession No. J02255.
Genbank® Accession No. SYNMMLPLN2.
Genbank® Accession No. SYNMMLPLN3.
Genbank® Accession No. SYNMMLPLN4.

Affiliated with

Also associated with

Rating

Retroviral vectors carrying senescent cell derived... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Retroviral vectors carrying senescent cell derived..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Retroviral vectors carrying senescent cell derived... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3549469