Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1994-01-14
1996-12-03
Guzo, David
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
4352402, 4353201, 435 691, 4351723, 4352351, 536 231, 536 234, 536 2372, 536 241, C12N 1586, C12N 510, C12P 2100, C07H 2104
Patent
active
055807666
ABSTRACT:
Retroviral vector particles are provided which contain: 1) oncoretroviral gag, pol, and env proteins, including an oncoretroviral gag capsid protein which has been mutated so as to contain a nuclear localization signal (NLS) sequence; and 2) at least one exogenous gene. The particles can be used to transduce non-proliferating cells, including stem cells and neurons. The presence of the NLS sequence allows the at least one exogenous gene to enter into the nucleus of a target cell, thus allowing integration of the gene into the genome of the target cell.
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Fidel Seth A.
Kennedy Scott P.
Mason James M.
Alexion Pharmaceuticals, Inc.
Fidel Seth A.
Guzo David
Klee Maurice M.
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