Retroviral vector particles

Details Retroviral vector particles Retroviral vector particles

1994-06-10

1998-01-20

Fleisher, Mindy

Chemistry: molecular biology and microbiology

Spore forming or isolating process

424 932, 424 9321, 4352401, 4353201, 536 2372, 536 241, C12N 1586, C12N 1563, C12N 1548, C12N 510

Patent

active

057100373

ABSTRACT:
A retroviral vector which includes a nucleic acid sequence encoding a retroviral envelope. The nucleic acid sequence encoding a retroviral envelope includes a first nucleic acid sequence encoding a first envelope portion which is a portion of MCF viral gp 70 protein, a nucleic acid sequence which encodes xenotropic envelope, a nucleic acid sequence which encodes an amphotropic envelope portion, and a nucleic acid sequence which encodes p15E protein. Such retroviral envelopes encoded by such nucleic acid sequence may be included in infectious viral particles. The infectious viral particles also may include gene(s) encoding therapeutic agents, and thus may be used in gene therapy.

REFERENCES:
Van Beveren et al., J. Virol. 41(2):542-556 (1982).
O'Neill et al., J. Virol. 53(1):100-106 (1985).
Adachi, et al., J. Virol., vol. 50, No. 3, pp. 813-821 (Jun. 1984).
Ott, et al., J. Virol., vol. 64, No. 2, pp. 757-766 (Feb. 1990).
Donahue, et al., J. Exp. Med., vol. 176, pp. 1125-1135 (Oct. 1992).

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