Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-06-07
1997-04-15
Dentz, Bernard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514563, 514595, 514542, 544168, 544400, 546332, 560 34, 560125, 560153, 560169, 562439, 562507, 562560, 564 56, 564 57, 564 27, A61K 31435, C07C 5528
Patent
active
056209770
ABSTRACT:
Urea-containing hydroxyethylamine peptide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
REFERENCES:
patent: H725 (1990-01-01), Gordon
patent: 4477441 (1984-10-01), Boger et al.
patent: 4514391 (1985-04-01), Gordon et al.
patent: 4548926 (1985-10-01), Matsueda et al.
patent: 4599198 (1986-07-01), Hoover
patent: 4616088 (1986-10-01), Ryono et al.
patent: 4668769 (1987-05-01), Hoover
patent: 4668770 (1987-05-01), Boger et al.
patent: 4757050 (1988-07-01), Natarajan et al.
patent: 4963530 (1990-10-01), Hemmi et al.
patent: 4977277 (1990-12-01), Rosenberg et al.
patent: 5157041 (1992-10-01), Handa et al.
Roberts et al, Science, 248, 358 (1990).
Krohn et al, J. Med. Chem., 34, 3340 (1991).
Getman et al, J. Med. Chem., 36, 288 (1993).
Reetz et al, Angew. Chem. Int. Ed., 26, 1141-1143 (1987).
J.R. Parikh, J. Amer. Chem. Soc., 89, 5505-5507 (1967).
Erickson et al, Science, 249:527-533 (1990).
Drugs of the Future, 1991, 16(3), 210-212.
Meek et al, Nature, 343:90-92, (1990).
Pept. Struct. Funct. Proc. Am. Pept. Sym. 8th ed. by V.J. Hunby and D.H. Rich, pp. 511-520 (1983).
McQuade et al, "A Synthetic HIV-1 Protease Inhibitor with Antiviral Activity Arrests HIV-Like Particle Maturation", Science, 274, 454 (1990).
Rosenberg et al, J. Med. Chem., 30, 1224-1228 (1987).
Fittkau, J. Prakt. Chem, 315, 1037-1044 (1973).
Bertenshaw Deborah E.
Freskos John N.
Getman Daniel P.
Heintz Robert M.
Lin Ko-Chung
Dentz Bernard
G.D. Searle & Co.
Ungemach, Esq. Frank S.
LandOfFree
Retroviral protease inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Retroviral protease inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Retroviral protease inhibitors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-360927