Retroviral protease inhibitors

Details Retroviral protease inhibitors Retroviral protease inhibitors

1995-07-24

1997-03-25

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514542, 514562, 514595, 544159, 546332, 558392, 560 34, 560125, 560150, 562507, 562430, 562556, 564 27, 564 57, 564 59, 564 56, A61K 31435, C07C 5528

Patent

active

056145225

ABSTRACT:
Urea-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

REFERENCES:
patent: H725 (1990-01-01), Gordon
patent: 4450164 (1984-05-01), Bristol et al.
patent: 4477441 (1984-10-01), Boger et al.
patent: 4514391 (1985-04-01), Gordon et al.
patent: 4548926 (1985-10-01), Matsueda et al.
patent: 4599198 (1986-07-01), Hoover
patent: 4616088 (1986-10-01), Ryono et al.
patent: 4668769 (1987-05-01), Hoover
patent: 4668770 (1987-05-01), Boger et al.
patent: 4757050 (1988-07-01), Natarajan et al.
patent: 4880938 (1989-11-01), Freidinger
patent: 4963530 (1990-10-01), Hemmi et al.
patent: 4977277 (1990-12-01), Rosenberg et al.
Roberts et al, "Rational Design of Peptide-based Proteinase Inhibitors," Science, 248, 358 (1990).
Erickson et al, "Design Activity, and 2.8.ANG. Crystal Structure of a C.sub.2 Symmetric Inhibitor Complexed to HIV-1 Protease," Science, 249, 527 (1990).
Pearl et al, "Sequence specificity of retroviral proteases" Nature, 328, (1987).
Martin, Drugs of the Future, 16(3), 210-212 (1991).
Meek et al, Letter to Nature, 343, 90-92 (1990).
McQuade et al, Science, 247, 454-456 (1989).
Rich et al, Peptide Inhibitors of Proteases, 511-520 (1990).
Rosenberg et al, J. Med. Chem., 30, 1224-1228 (1987).

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