Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-05-31
1998-05-26
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514385, 514412, 514416, 548200, 548452, 548470, 548492, 548515, 548537, A01N 4336
Patent
active
057565341
ABSTRACT:
N-heterocyclic moiety containing hydroxyethylamine compounds of the formula: ##STR1## such as -methyl-3-(methysulfonyl)-1-oxopropyl!amino!-4-phenylbutyl!-, retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
REFERENCES:
patent: 4450164 (1984-05-01), Bristol et al.
patent: 4477441 (1984-10-01), Boger et al.
patent: 4514391 (1985-04-01), Gordon et al.
patent: 4548926 (1985-10-01), Matsueda et al.
patent: 4599198 (1986-07-01), Hoover
patent: 4616088 (1986-10-01), Ryono et al.
patent: 4668769 (1987-05-01), Hoover
patent: 4668770 (1987-05-01), Boger et al.
patent: 4757050 (1988-07-01), Natarajan et al.
patent: 4880938 (1989-11-01), Freidinger
patent: 4963530 (1990-10-01), Hemmi et al.
patent: 4977277 (1990-12-01), Rosenberg et al.
patent: 5157041 (1992-10-01), Handa et al.
Drugs of the Future, 1991, 16(3):210-212.
Nature, vol. 328, No. 6130, Aug. 6-12, 1987, p. 482.
Pept. Struct. Funct. Proc. Am. Pept. Sym. 8th ed. by V.J. Hunby and D.H. Rich (1983) pp. 511-520.
Roberts, et al., "Rational Design of Peptide-Based HIV Proteinase Inhibitors," Science, 248, 358 (1990).
Erickson et al., "Design Activity and 2.8 .ANG.Crystal Structure of a C.sub.2 Symmetric Inhibitor Complexed to HIV-1 Protease," Science, 249, 527 (1990).
Meek, et al., "Inhibition of HIV-1 Protease in Infected T-lymphocytes by Synthetic Peptide Analogues," Nature, 343, 90 (1990).
McQuade, et al., "A Synthetic HIV-1 Protease Inhibitor With Antiviral Activity Arrests HIV-Like Particle Maturation," Science, 247, 454 (1990).
Rosenberg, S. H. et al., "Novel Renin Inhibitors Containing Analogues of Statine Retro-Inverted at the C-Termini: Specificity at the P.sub.2 Histidine Site", J. Med. Chem., 30, pp. 1224-1228, (1987).
Sali, A. et al., "High-resolution X-Ray Diffraction Study of the Complex Between Endothiapepsin and an Oligopeptide Inhibitor: the Analysis of the Inhibitor Binding and Description of the Rigid Body Shift in the Enzyme", The EMBO Journal, vol. 8, No. 8, pp. 2179-2188, (1989).
Current Topics in AIDS, edited by Gottlieb, M.S. et al, 1987, John Wiley & Sons Ltd. pp. 51-55.
Laurence, J. et al, The Lancet, 1 Aug. 1992, vol. 340, pp. 273-274.
Clare Michael
DeCrescenzo Gary A.
Freskos John Nicholas
Getman Daniel P.
Heintz Robert M.
Dahlen Garth M.
Ivy C. Warren
Monsanto Company
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