Retroviral protease inhibiting compounds

Details Retroviral protease inhibiting compounds Retroviral protease inhibiting compounds

1996-09-24

1999-05-18

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514885, 4241851, 544242, 548217, 5483051, 5483054, 549546, A61K38/05;39/00

Patent

active

059050683

ABSTRACT:
A compound of the formula: ##STR1## is disclosed as a retroviral protease inhibitor compound. Also disclosed are methods and compositions for inhibiting an HIV infection.

REFERENCES:
Caplus Abstract No. 118: 192283 (1993) to Kempf et al. EP 486 948 (May, 1992).
Chen, X., et al., "Novel Furofuran Containing HIV Protease Inhibitors", Book of Abstracts, 211th ACS National Meeting, New Orleans, LA, (Mar. 24-28, 1996).
Kempf, D. J., et al., "Evaluation of Substituted Benzamides as P2 Ligands for Symmetry-based Inhibitors of HIV Protease", Bioorganic & Medicinal Chemistry Letters, 5(22):2725-2728 (1995).
Kempf, D. J., et al., "HIV Protease Inhibitors", Current Pharmaceutical Design, 2:225-246 (1996).

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