Retroviral gene transfer into diploid fibroblasts for gene thera

Details Retroviral gene transfer into diploid fibroblasts for gene thera Retroviral gene transfer into diploid fibroblasts for gene thera

1987-02-13

1993-06-15

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

424 93A, 424 93B, 4351723, 435183, 435193, 435227, 4352401, 4353201, 935 32, 935 57, 935 62, 935 70, 935 71, C12N 510, C12N 1586

Patent

active

052197409

ABSTRACT:
A process of mammalian gene therapy. Explanted fibroblasts are genetically modified by introducing a retroviral construct containing a nucleotide sequence encoding for a therapeutic substance. The genetically modified fibroblasts are implanted into a mammalian subject.

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This invention was made with Government support under one or more of grants CA41455, CA09351, AG00057, and AI19565 awarded by the National Institutes of Health. The Government has certain rights in this invention.

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