Retroviral envelopes having modified hypervariable polyproline r

Details Retroviral envelopes having modified hypervariable polyproline r Retroviral envelopes having modified hypervariable polyproline r

1997-05-14

1999-12-21

Eisenschenk, Frank C.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

4353201, 536 231, C12N 701, C12N 1509, C12N 1563, C12N 1570

Patent

active

060047984

ABSTRACT:
A retroviral vector particle having a modified retroviral envelope polypeptide. The retroviral envelope polypeptide includes the hypervariable polyproline region, or hinge region, and the hypervariable polyproline region, or hinge region is modified to include a targeting polypeptide including a binding region which binds to a ligand. Such a retroviral vector may be "targeted" to various cells for delivery of genetic material to such cells.

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patent: 5723287 (1998-03-01), Russell et al.
Salmons, et al., Human Gene Therapy, vol. 4, pp. 129-141 (1993).
Barinaga, Science,vol. 266, p. 1326 (Nov. 25, 1994).
Kasahara, et al., Science, vol. 266, pp. 1373-1376 (Nov. 25, 1994).
Wong, et al., Bone Marrow Transplantation Experimentation, Abstract 1001 (Dec. 6, 1994).

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