Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Canine cell – per se
Patent
1994-12-30
1997-10-28
Crouch, Deborah
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Canine cell, per se
435366, 435371, 4353201, 536 235, C12N 500, C12N 1563, C07H 2104
Patent
active
056817460
ABSTRACT:
Retroviral vectors for directing expression of full length factor VIII in transduced host cells, plasmids encoding the same, and host cells transformed, transfected, or transduced therewith are disclosed. Also disclosed are retroviral particles comprising such retrovital vectors, as are methods for making such particles in suitable packaging cells. Retroviral particles so produced may be amphotropic, ecotropic, polytropic, or xenotropic; alternatively, they may comprise chimeric or hybrid envelope proteins to alter host range. Also described are retrovital particles comprising retroviral vectors for directing full length factor VIII expression which are complement resistant. Pharmaceutical compositions comprising retrovital particles of the invention are also disclosed, as are methods of treating mammals, particularly humans, afflicted with hemophilia.
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Bodner Mordechai
Chang Stephen
De Polo Nicholas J.
Hsu David Chi-Tang
Respess James G.
Blackburn Robert P.
Chiron Viagene, Inc.
Crouch Deborah
Kruse Norman J.
Schmuck Jill
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