Retro-peptide fibroblast growth factor which blocks FGF receptor

Details Retro-peptide fibroblast growth factor which blocks FGF receptor Retro-peptide fibroblast growth factor which blocks FGF receptor

1993-10-07

1998-08-04

Spector, Lorraine

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424400, 530326, A61K 3810, C07K 708, C07K 1471

Patent

active

057893829

ABSTRACT:
A fibroblast growth factor receptor-blocking peptide is provided. In one embodiment, the peptide is a retro-peptide of the fibroblast growth factor receptor. The receptor-blocking peptide may be used in a therapeutic method for treatment of viral diseases, hypervascular diseases, and tumors.

REFERENCES:
patent: 4360516 (1982-11-01), Freidinger
patent: 5132408 (1992-07-01), Baird
patent: 5192746 (1993-03-01), Lobl
patent: 5252718 (1993-10-01), Baird
J. Kyte & R.F. Doolittle J. Mol. Biol. 157:105-132 1982.
P. Guptasarma FEBS Lett. 310(3):205-210 Oct. 1992.
CF Hayward & J.S. Morley Eur. Peptide Symp. 13:28798 Apr. 1974.
A. Baird et al. PNAS 85:2324-2328 1988.
A. Ricouart et al. Biochem Biophys Res Comm. 165(3) 1382-1390 1989.

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