Retro-inverso peptides derived from interleukin-6

Details Retro-inverso peptides derived from interleukin-6 Retro-inverso peptides derived from interleukin-6

2006-11-14

2006-11-14

Gupta, Anish (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S002600, C530S300000, C530S326000

Reexamination Certificate

active

07135461

ABSTRACT:
Retro-inverso peptides derived from interleukin-6 (IL-6) having between 17 and about 40 amino acids and including the sequence shown in SEQ ID NO: 1. These peptides have the same activity as native IL-6 and also have neurotrophic activity. Because of the D-amino acid linkage in the peptides, they are less susceptible to proteolytic degradation in vivo.

REFERENCES:
patent: 4730036 (1988-03-01), Ralph et al.
patent: 5376544 (1994-12-01), Lazarus et al.
patent: 5700909 (1997-12-01), O'Brien
patent: 6217871 (2001-04-01), Rose et al.
patent: WO 9838357 (1998-09-01), None

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