Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides
Patent
1991-11-26
1993-06-08
Lee, Lester L.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Synthesis of peptides
530323, 530332, 530330, 530334, A61K 3702, C07K 500, C07K 700, C07K 1500
Patent
active
052180891
ABSTRACT:
New analogues of thymopentin (TP5) and of its tetrapeptide fragment (TP5.sup.1-4) containing two non-contiguous retro-inverted bonds in the peptide chain are described which are of the general formula (I) ##STR1## where R is hydrogen or an acyl radical, and R.sup.1 is an --OR.sup.2 group or an ##STR2## group where R.sup.2 is a hydrogen atom or a hydrocarbon radical, and R.sup.3 is a hydrogen atom or a hydroxyl group, and the corresponding pharmaceutically acceptable salts of acid or basic addition, possess immunomodulating activity.
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Denes et al., Chemical Abstracts, vol. 107, 1987, p. 60. Abst No: 211960d.
Mariotti Sabina
Nencioni Luciano
Sisto Alessandro
Verdini Antonio S.
Villa Luigi
Davenport A. M.
Lee Lester L.
Sclavo S.p.A.
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