Retro-inverso analog of the (5-14) decapeptide of equine angiote

Details Retro-inverso analog of the (5-14) decapeptide of equine angiote Retro-inverso analog of the (5-14) decapeptide of equine angiote

1984-05-22

1985-12-24

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

045605050

ABSTRACT:
There is provided an analog of the (5-14) decapeptide of equine angiotensinogen which is partially inverted at the Phe-Val bond, and which has the formula ##STR1## This retro-inverso analog inhibits renin with high resistance to enzymatic degradation and it can be used in the treatment of renin-dependent hypertension.

REFERENCES:
patent: 4424207 (1984-01-01), Szelke et al.
patent: 4439360 (1984-03-01), Verdini et al.
Pallai et al., American Peptide Symposium, (7th: 1981: U. of Wisconsin), "Configuration of Substituted Malonyl and Gem-Diamino Derivatives of Peptides", pp. 85-88.
Burton et al., Medical Sciences, vol. 77, No. 9, 5476-5479, (1980).
Cody et al., Biochemical and Biophysical Research Communications, vol. 97, No. 1, 230-235, (1980).
Radhakrishna et al., J. Org. Chem., vol. 44, No. 10, 1746-1747, (1979).

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