Retro-inversion peptides that target GIT receptors and...

Details Retro-inversion peptides that target GIT receptors and... Retro-inversion peptides that target GIT receptors and...

1999-11-19

2009-02-17

Robinson, Hope A (Department: 1652)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S300000, C514S002600, C514S012200

Reexamination Certificate

active

07491796

ABSTRACT:
Retro-inverted forms of GIT targeting agents that target specific receptor sites in vivo and/or promote uptake of active agents and/or enhance active agent delivery across the GIT into the systemic circulation are provided. These retro-inverted peptides and compositions containing these retro-inverted peptides can be used to deliver an active agent, such as a drug or a drug-containing nano- or microparticle for treatment of a condition in a subject in need of the drug, in vivo. Additionally, the invention provides antibodies which are capable of immunospecifically binding the retro-inverted peptides.

REFERENCES:
patent: 6703362 (2004-03-01), Alvarez et al.
patent: WO98/51325 (1998-11-01), None

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