Retro-anandamides, high affinity and stability cannabinoid...

Details Retro-anandamides, high affinity and stability cannabinoid... Retro-anandamides, high affinity and stability cannabinoid...

2007-10-02

2007-10-02

Oh, Taylor Victor (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

C554S067000, C554S106000, C564S192000

Reexamination Certificate

active

10110862

ABSTRACT:
Novel retro-anandamides are presented which have high affinities for the cannabinoid CB1 and/or CB2 receptor sites. Further, most of the analogs exhibit greater metabolic stability than arachidonylethanolamide. The improved receptor affinity and selectivity and/or greater metabolic stability make these analogs therapeutically useful as medications in individuals and animals for treatment of pain, glaucoma, epilepsy, nausea associated with chemotherapy, as well as suppression of the immune system, enhancement of appetite and in treatment of certain mental disorders.

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