Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai
Patent
1991-04-09
1996-05-28
Lone, Werren B.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
C-o-group doai
435155, 435244, 514715, 514519, 514546, 514613, 514763, 568822, 568823, 568824, 568828, C07C 3518, C07C 3768
Patent
active
055212212
ABSTRACT:
This invention provides a purified retro-retinoid compound characterized by a molecular mass of about 302 daltons. Also provided by this invention is a method of enhancing the growth of a cell in a vitamin A reduced environment which comprises contacting the cell with an effective growth enhancing amount of a compound having a structure: ##STR1## wherein the configuration of the C6, C8, C10 and C12 double bond independently is Z or E and the absolute configuration at C-14 is independently R or S; wherein R.sub.1 is alkyl, alkyl halide, alcohol, ester, ether, aldehyde, ketone, carboxylic acid, carboxylic ester, acid halide, amide, nitrile, or amine; and wherein R.sub.2 is hydroxyl, halide, alkoxy, ester, alkyl, alcohol, ether, aldehyde, ketone, carboxylic acid, carboxylic ester, nitrile, amine, azide, alkyl halide, acid halide, acid azide, or amide; or wherein R.sub.1 and R.sub.2 are replaced by a 14, 15-oxirane group; and wherein the retro structure is alpha or gamma. Further provided are a method for enhancing transcription of a gene regulated by retinoid in a cell, or a method for enhancing an immune response in a subject.
REFERENCES:
patent: 4825006 (1989-04-01), Otera et al.
patent: 4906795 (1990-03-01), Grosselin et al.
Garbe et al, "Chemical Abstracts", vol. 117 (9) p 88604t (1992)
Buck et al, "Chemical Abstracts", vol. 116 p 104269z (1992).
Buck Jochen
Derguini Fadila
Hammerling Ulrich
Nakanishi Koji
Lone Werren B.
Sloan-Kettering Institute for Cancer Research
The Trustees of Columbia University in the City of New York
White John P.
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