Retionoic acid treatment of cardiac arrhythmia

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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514725, A61K 3120, A61K 3107

Patent

active

055763499

ABSTRACT:
Disclosed is a method for terminating an existing potentially lethal cardiac arrhythmia, or preventing an imminent potentially lethal cardiac arrhythmia. The method involves administration of all-trans-retinoic acid or an antiarrhythmically active analog. Antiarrhythmic effects of all-trans-retinoic acid occur within minutes.

REFERENCES:
patent: 4678808 (1987-07-01), Ward et al.
patent: 5310554 (1994-05-01), Haigh
Airaksinen et al., "Association between Silent Coronary Artery Disease, Diabetes, and Autonomic Neuropathy. Fact or Fallacy?" Diabetes Care (1992) 15:288-292.
Aronow, "Prevalence of Presenting Symptoms of Recognized Acute Myocardial Infarction and of Unrecognized Healed Myocardial Infarction in Elderly Patients," Am. J. Cardiol. (1987) 60:1182.
Billman, "Effect of Calcium Channel Antagonists on Cocaine-Induced Malignant Arrhytmias: Protection against Ventricular Fibrillation," J. Pharm. and Exp. Ther. 266:407-416 (1993).
Billman, "Effect of Calcium Channel Antagonists on Suceptibility to Sudden Cardiac Death: Protection from Ventricular Fibrillation," J. Pharm. Expt. Therap. (1989) 248:1334-1342.
Billman et al., "Elevated Myocardial Calcium and its Role in Sudden Cardiac Death," FASB 5:2586-92 (1991).
Billman, "Ro 40-5967, a Novel Calcium Channel Antagonist, Protects Against Ventricular Fibrillation," Eur. J. Pharmacol. (1992) 229:179-187.
Billman, "The Calcium Channel Antagonist, Flunarizine, Protects Against Ventricular Fibrillation," Eur. J. Pharmacol. (1992) 212:231-235.
Hallaq et al., "Protective effect of eicosapentaenoic acid on ouabain toxicity in neonatal rat cardiac myocytes," Proc. Natl. Acad. Sci. USA (1990) 87:7834-7838.
Hallaq et al., "Modulation of Dihydropyridine-sensitive Calcium Channels in Heart Cells by Fish Oil Fatty Cells," Proc. Natl. Acad. Sci. USA (1992) 89(5):1760-1764
Juan et al., "Effect of exogenous 5, 8, 11, 14, 17-eicosapentaenoic acid on cardiac anaphylaxis," Br. J. Pharmac. (1987) 90:315-325.
Kamp et al., "pH gradients across phospholipid membranes caused by fast flip-flop of un-ionized fatty acids," Proc. Natl. Acad. Sci. USA 89:11367-11370 (1992).
Kang et al., "Free long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes," Proc. Natl. Acad. Sci. USA 92:3997-4001 (1995).
Kang et al., "Effects of long-chain polyunsaturated fatty acids on the contraction of neonatal rat cardiac myocytes," Proc. Natl. Acad. Sci. USA 91:9886-9890 (1994).
Leaf et al., "Cardiovascular Effects of n-3 Fatty Acids," New England Journal of Medicine (1988) 318:549-557.
Leaf, "Cardiovascular Effects of Fish Oils: Beyond the Platelet," Circulation (1990) 82:624-628.
McLennan et al., "Dietary Fish Oil Prevents Ventricular Fibrillation Following Coronary Artery Occlusion and Reperfusion," American Heart Journal (1988) 116:709-717.
McLennan et al., "Influence of Dietary Lipids on Arrhythmias and Infarction after Coronary Artery Ligation in Rats," Can. J. Physiol. Pharmacol. (1985) 63:1411-1417.
Makita et al., "Successful Management of Life-Threatening Ventricular Arrhythmias with Propafenone in a Hemodialysis Patient," Current Therapeutic Research (1991) 49:954-960.
Steen et al., "Myocardial Reinfarction After Anesthesia and Surgery," JAMA (1978) 239(24):2566-2570.
Xiao et al., "Blocking effects of polyunsaturated fatty acids in Na+ channels of neonatal rat ventricular myocytes," Proc. Nat. Acad. Sci.., 92:1000-11004 (1995).
Yamashita et al., "Effect of Eicosapentaenoic and Docosahexaenoic Acid on Natural Killer Cell Activity in Human Peripheral Blood Lymphocytes," Clinical Immunology and Imunopathology (1991) 59:335-345.
Yamazaki et al., "Changes in fatty acid composition in rat blood and organs after infusion of docosahexaenoic acid ethyl ester.sup.1-3," Am. J. Clin. Nutr. (1991) 53:620-627.

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