Retinol derivatives and uses thereof

Details Retinol derivatives and uses thereof Retinol derivatives and uses thereof

1992-05-06

1998-09-29

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514725, 549453, 549512, 549551, 549554, 549561, 549563, 552 10, 552 11, 552 12, 558430, 564123, 564152, 564153, 562867, 568823, 568824, 568825, A61K 3722, C07D31774

Patent

active

058146121

ABSTRACT:
The present invention provides a purified retinoid compound characterized by a molecular mass of about 320 daltons and an atomic composition of C.sub.20 H.sub.32 O.sub.3. The present invention also provides a purified retinoid compound having the structure: ##STR1## wherein the configuration of the C7, C9, and C11 double bond independently is Z or E and the absolute configuration at C13 and C14 is independently R or S; wherein R1 is alkyl, alkyl halide, alcohol, ester, ether, aldehyde, ketone, carboxylic acid, carboxylic ester, acyl halide, amide, nitrile, or amine; R2 and R3 are independently hydroxyl, halide, alkoxy, ester, alkyl, alcohol, ether, aldehyde, ketone, carboxylic acid, carboxylic ester, nitrile, amine, azide, alkyl halide, acid halide, acid azide, or amide; or wherein R2 and R3, or R1 and R2 are replaced by a 13,14-oxirane or a 14,15-oxirane group, respectively.

REFERENCES:
patent: 5124083 (1992-06-01), Shealy

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