Retinoid-based compositions and method for preventing adhesion f

Details Retinoid-based compositions and method for preventing adhesion f Retinoid-based compositions and method for preventing adhesion f

1995-01-17

1996-07-09

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424422, 424443, 424484, 424489, 514559, A61K 9127

Patent

active

055342612

ABSTRACT:
Compositions and methods for prevention of adhesion formation, whereby an effective amount of at least one retinoid, e.g., all trans retinoic acid, is administered for a period of time sufficient to permit tissue repair. The retinoid is preferably administered in conjunction with a delivery vehicle (e.g., microcapsules, microspheres, biodegradable polymer films, lipid-based delivery systems such as liposomes and lipid foams, viscous instillates and absorbable mechanical barriers) useful for maintaining local concentrations of the compound at the injury site at an effective level.

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