Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-11-28
1998-01-13
Carlson, Karen C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 78, 435 721, 435 72, 435367, 435365, 435358, 435357, 435349, 435348, 435325, 4352523, 4353201, 435 78, 435 691, 536 241, 536 231, 536 232, C12Q 168, C12P 2106, C12N 1500, C07H 1700
Patent
active
057078009
ABSTRACT:
DNA segments have been discovered, and characterized by sequence, which are response elements operative to confer responsiveness to retinoic acid, or derivatives thereof, for the transcriptional activation of promoters in cells. By using transcriptional control regions comprising response elements of the present invention in combination with a functional promoter, it is now possible to provide recombinant DNA vectors containing a gene, the transcription (and, thereby, also expression) of which is under the control of a promoter, the transcriptional activity of which is responsive to (and increased by) retinoic acid or derivatives thereof.
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Evans Ronald M.
Kliewer Steven A.
Mangelsdorf David John
Umesono Kazuhiko
Carlson Karen C.
Kleinsmith David F.
Reiter Stephen E.
The Salk Institute for Biological Studies
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