Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1994-01-11
1996-08-20
Fitzgerald, David L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530324, 435 691, C07K 14705
Patent
active
055480632
ABSTRACT:
A human retinoic acid receptor alpha protein is disclosed. The receptor is encoded by the cDNA insert of plasmid phRAR1, which has been deposited with ATCC. Methods employing chimeric receptors derived from the retinoic acid receptor are illustrated which demonstrate that the ligand for the new receptor is the retinoid, retinoic acid.
REFERENCES:
patent: 4859609 (1989-08-01), Dull et al.
patent: 5171671 (1992-12-01), Evans et al.
patent: 5274077 (1993-12-01), Evans et al.
Arriza et al., "Cloning of Human Mineralocorticoid Receptor Complementary DNA: Structural and Functional Kinship with the Glucocorticoid Receptor" Science 237:268-275 (1987).
Brand et al., "Identification of a Second Human Retinoic Acid Receptor" Nature 332:850-853 (1988).
Devereux et al., "A comprehensive set of sequence analysis programs for the VAX" Nucleic Acid Res. 12:387-395 (1984).
Evans, R., "The Steroid and Thyroid Hormone Receptor Superfamily" Science 240:889-895 (1988).
Giguere et al., "Functional Domains of the Human Glucocorticoid Receptor" Cell 46:645-652 (1986).
Giguere et al., "Identification of a Receptor for the Morphogen Retinoic Acid" Nature 330:624-629 (1987).
Giguere et al., "Identification of a new class of steroid hormone receptors" Nature 331: 91-94 (1988).
Glass et al., "A c-erb-A binding site in rat growth hormone gene mediates trans-activation by thyroid hormone" Nature 329:738-741 (1987).
Glass et al., "The Thyroid Hormone Receptor Binds with Opposite Transcriptional Effects to a Common Sequence Motif in Thyroid Hormone and Estrogen Response Elements" Cell 54:313-323 (1988).
Green, S. and Chambon, P., "Oestradiol induction of a glucocorticoid-responsive gene by a chimaeric receptor" Nature 325:75-78 (1987).
Green, S., "Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A" Nature 320:134-139 (1986).
Haussler et al., "Specific high-affinity binding and biologic action of retinoic acid in human neuroblastoma cell lines" Proc. Natl. Acad. Sci., USA 80:5525-5529 (1983).
Hollenberg et al., "Primary structure and expression of a functional human glucocorticoid receptor cDNA" Nature 318:635-641 (1985).
Hollenberg et al., "Colocalization of DNA-Binding and Transcriptional Activation Functions in the Human Glucocorticoid Receptor" Cell 49:39-46 (1987).
Hollenberg, S. M., and Evans, R. M., "Multiple and Cooperative Transactivation Domains of the Human Glucocorticoid Receptor" Cell 55:899-906 (1988).
Krieg, P. A., and Melton, D. A., "Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs" Nucleic Acid Res. 12:7057-7070 (1984).
Kumar et al., "Functional Domains of the Human Estrogen Receptor" Cell 51:941-951 (1987).
Miesfeld et al., "Glucocorticoid Receptor Mutants That Define a Small Region Sufficient for Enhancer Activation" Science 236:423-427 (1987).
Petkovich et al., "A Human Retinoic Acid Receptor Which Belongs to the Family of Nuclear Receptors" Nature 330:444-450 (1987).
Roberts, A. B., and Sporn, M. B., "Cellular Biology and Biochemistry of the Retinoids" The Retinoids Sporn et al., eds., Academic Press, New York, 1:235-279 (1984).
Robertson, M., "Towards a Biochemistry of Morphogenesis" Nature 330:420-421 (1987).
Russell et al., "Separation of Retinoid Receptors From Cultured Retinoblastoma Cells" Biochimica et Biophysica Acta 543:586-589 (1978).
Sap et al., "The c-erb-A protein is a high-affinity receptor for thyroid hormone" Nature 324:635-640 (1986).
Sigler, P. B., "Acid blobs and negative noodles" Nature 333:210-212 (1988).
Suggs et al., "Use of synthetic oligonucleotides as hybridization probes: Isolation of cloned cDNA sequences for human .beta..sub.2 -microglobulin" Proc. Natl. Acad. Sci., USA 78(11):6613-6617 (1981).
Thompson et al., "Identification of a Novel Thyroid Hormone Receptor Expressed in the Mammalian Central Nervous System" Science 237:1610-1614 (1987).
Tora et al., "The N-terminal region of the chicken progesterone receptor specifies target gene activation" Nature 333:185-188 (1988).
Umesono et al., "Retinoic Acid and thyroid hormone induce gene expression through a common responsive element" Nature 336:262-265 (1988).
Webster et al., "The Hormone-Binding Domains of the Estrogen and Glucocorticoid Receptors Contain an Inducible Transcription Activation Function" Cell 54:199-207 (1988).
Weinberger et al., "Domain structure of human glucocorticoid receptor and its relationship to the v-erb-A oncogene product" Nature 318:670-672 (1985).
Weinberger et al., "The c-erb-A gene encodes a thyroid hormone receptor" Nature 324(6098):641-646 (1986).
Evans Ronald M.
Giguere Vincent
Ong Estelita S.
Segui Prudimar S.
Thompson Catherine C.
Fitzgerald David L.
Reiter Stephen E.
The Salk Institute for Biological Studies
LandOfFree
Retinoic acid receptor alpha proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Retinoic acid receptor alpha proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Retinoic acid receptor alpha proteins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2331484