Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Rodent cell – per se
Patent
1997-09-25
2000-09-12
Railey, II, Johnny F.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Rodent cell, per se
435366, 435377, 435379, 435384, 435385, 435455, C12N 506, C12N 508, C12N 510
Patent
active
061176753
ABSTRACT:
The invention relates to stem cells isolated from the retina of mammals and retinal cells differentiated from these stem cells. The invention also relates to a method of isolating retinal stem cells and inducing retinal stem cells to produce retinal cells. Retinal stem cells may also be induced in vivo to produce retinal cells. The invention also includes pharmaceuticals made with retinal stem cells or retinal cells which may be used to restore vision lost due to diseases, disorders or abnormal physical states of the retina. The invention includes retinal stem cell and retinal cell culture systems for toxicological assays, for isolating genes involved in retinal differentiation or for developing tumor cell lines.
REFERENCES:
Kohn.,Clin. Exp. Immunol. 107:54-57 (1997).
Anchan et al., "EGF and TGF.alpha. Stimulate Retinal Neuroepithelial Cell Proliferation In Vitro", Neuron, 6:923-937 (1991).
Anglade et al., "The Diagnosis and Management of Uveitis", Drugs, 49(2):213-223 (1995).
Bloom et al., "The Diagnosis of Cytomegalovirus Retinitis", Anals of Internal Medicine, 109(12):963-968 (1988).
Cepko et al., "Cell fate determination in the vertebrate retina", PNAS 93:589-595 (1996).
Craig et al., "In Vivo Growth Factor Expansion of Endogenous Subependymal Neural Precursor Cell Populations in the Adult Mouse Brain", The Journal of Neuroscience, 16(8):2649-2658 (1996).
Dyment, "Eye Disorders", Pharmacy Practice, 29-32 (1989).
Holt et al., "Giant Papillary Conjunctivitis", Pharmacist, 68-80 (1992).
Jeffery, "The albino retina: an abnormality that provides insight into normal retinal development" TINS 20(4):165-169 (1997).
Lehndahl et al., "CNS sTem cells Express a New Class of Intermediate Filament Protein" Cell 60:585-595 (1990).
Lightman, "Uvetis: Management"The Lancet 338:1501-1503 (1991).
Lillien et al., "Control of proliferation in the retina: temporal changes in responsiveness to FGF and TGF.alpha.", Development, 115:253-266 (1992).
Liu et al., "Developmental Expression of a Novel Murine Homeobox Gene (Chx 10): Evidence for Roles in Determination of the Neuroretina and Inner Nuclear Layer" Neuron 13:377-393 (1994).
Luke et al., "Transplantation--an update" On Continuing Practice 17(2):35-39 (1990).
Morshead et al., "Neural Stem Cells in the Adult Mammalian Forebrain: A Relatively Quiescent Subpopulation of Subependymal Cells" Neuron 13:1071-1082 (1994).
Opas et al., "bFGF-Induced Transdifferentiation of RPE to Neuronal Progenitors is Regulated by the Mechanical Properties of the Substratum" Development Biology 161:440-454 (1994).
Park et al., "Induction of Retinal Regeneration in Vivo by Growth Factors" Developmental Biology 148:322-333 (1991).
Weiss et al., "Is there a neural stem cell in the mammalian forebrain" TINS Review 19(9):1-13 (1996).
Chiasson Bernard
McInnes Roderick
Tropepe Vincenzo
van der Kooy Derek
HSC Research and Development Limited Partnership
Railey II Johnny F.
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