Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell
Reexamination Certificate
2003-10-06
2010-11-02
Kim, Taeyoon (Department: 1651)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Animal or plant cell
C424S424000, C424S427000, C424S571000, C424S583000, C435S371000
Reexamination Certificate
active
07824671
ABSTRACT:
The present invention relates to a composition for implantation in the subretinal space of an eye, the composition including amniotic membrane, which may be cryopreserved human amniotic membrane, and a plurality of retinal pigment epithelial (RPE) cells or RPE equivalent cells present at the amniotic membrane. The amniotic membrane may be intact, epithelially denuded, or otherwise treated. The invention includes the use of amniotic membrane for the culturing of RPE cells thereon, forming a surgical graft for replacement of Bruch's membrane as a substrate, and for the transplanting of RPE cells to the subretinal space. The composition does not elicit immunological reactions to alloantigens or to RPE specific autoantigens; and exerts anti-inflammatory, and angiogentic, and anti-scarring effects. The invention includes methods and kits for making or using composites including amniotic membrane and RPE cells. Also disclosed is a device for harvesting RPE cells.
REFERENCES:
patent: 6045791 (2000-04-01), Liu
patent: 6152142 (2000-11-01), Tseng
patent: 6326019 (2001-12-01), Tseng
patent: 2002/0039788 (2002-04-01), Isseroff
patent: 2003/0208266 (2003-11-01), Tsai
patent: 2004/0009590 (2004-01-01), Tan et al.
patent: 2005/0026279 (2005-02-01), Tseng
patent: 2110531 (1983-06-01), None
patent: WO03018040 (2003-03-01), None
Dutt et al. 1991 Extracellular matrix mediated growth and differentiation in human pigment epithelial cell line 0041. Curr Eye Res. Dec. 1991;10(12):1089-100. (Abstract only).
Dutt et al. 1991. Extracellular matrix mediated growth and differentiation in human pigment epithelial cell line 0041. Current Eye Research. 10(12):1089-1100.
Dua et al. 1999. Amniotic membrane transplantation. Br. J. Ophthalmol. 83:748-752.
Grueterich et al. 2002. Connexin 43 expression and proliferation of human limbal epithelium on intact and denuded amniotic membrane. Invest. Ophthalmol. Vis. Sci. 43:63-71.
Justia.com. 2008. US 40 C.F.R.§141.2. Definition. http://law.justia.com/us/cfr/title40/40-22.0.1.1.3.1.16.2.html. p. 1-9.
Merriam-Webster online dictionary. 2008. Definition of “confluent” http://www.merriam-webster.com/dictionary/confluent. p. 1-2.
Snodderly et al. 2002. Retinal Pigment Epithelial Cell Distribution in Central Retina of Rhesus Monkeys.Investigative Ophthalmology & Visual Science, Sep. 2002, vol. 43, No. 9; p. 2815-2818.
Robb. 1985. Regional Changes in Retinal Pigment Epithelial Cell Density During Ocular Development. Invest Ophthalmol Vis Sci 26:614-620.
International Search Report dated Jan. 25, 2005, for PCT/US03/31464 (3 sheets), Notification of Transmittal (1 pg.), Cover sheet of WO 2004/033635 A3.
Binder, S., et al., “Transplantation of Autologous Retinal Pigment Epithelium in Eyes With Foveal Neovascularization Resulting From Age-Related Macular Degeneration: A Pilot Study,”Am J Ophthalmol, 133(2): 215-25 (2002).
Phillips, S.J., et al., “Autologous Transplantation of Retinal Pigment Epithelium After Mechanical Debridement of Bruch's Membrane,”Invest Ophthalmol Vis Sci., In Press 1-11 (2002).
Pfeffer, B.A., “Improved Methodology for Cell Culture of Human and Monkey Retinal Pigment Epithelium,”Prog. Retin. Eye Res., Chapter10: 251-91 (1991).
Flood, M.T., et al., “Growth Characteristics and Ultrastructure of Human Retinal Pigment Epithelium in Vitro,”Invest Ophthalmol Vis Sci., 19:1309-20 (1980).
Hu, J., Bok, D., “A cell culture medium that supports the differentiation of human retinal epithelium into functionally polarized monolayers,”Molecular Vision, 7:14-19 (2000).
Dutt, K, et al., “Extracellular matrix mediated growth and differentiation in human pigment epithelial cell line 0041,”Current Eye Research, 10 (12): 1089-100 (1991).
Lu, L., et al., “Retinal pigment epithelium engineering using synthetic biodegradable polymers,”Biomaterials, 22: 3345-55 (2001).
Kim, J.C., Tseng, S.C.G., “Transplantation of Preserved Human Amniotic Membrane for Surface Reconstruction in Severely Damaged Rabbit Corneas,”Cornea, 14:473-84 (1995).
Tezel, T.H., et al., “Fate of Human Retinal Pigment Epithelial Cells Seeded onto Layers of Human Bruch's Membrane,”Invest.Ophthalmol.Vis.Sci., 40:467-76 (1999).
Dua, H.S., Azuara-Blanco, A., “Amniotic membrane transplantation,”Br.J.Ophthalmol, 83:748-52 (1999).
Grueterich, M., Espana, E., Tseng, S.C.G., “Connexin 43 Expression and Proliferation of Human Limbal Epithelium on Intact and Denuded Amniotic Membrane,”Invest Ophthalmol Vis.Sci, 43:63-71 (2002).
Meller, D., Tseng, S.C.G., “Conjunctival Epithelial Cell Differentiation on Amniotic Membrane,”Invest. Ophthalmol. Vis. Sci., 40:878-86 (1999).
Lu, L., et al., “Retinal pigment epithelium cell culture on thin biodegradable poly(DL-lactic-co-glycolic acid) films,”J Biomater. Sci. Polymer Edn., 9(11):1187-205 (1998).
Singh, S., et al., “Natural and artificial substrates for retinal pigment epithelial monolayer transplantation,”Biomaterials, 22:3337-343 (2001).
DelPriore, L., Tezel, T., “Reattachment Rate of Human Retinal Pigment Epithelium to Layers of Human Bruch's Membrane,”Arch Ophthalmol, 116: 335-41 (1998).
Koizumi, N., et al., “Cultivation of Corneal Epithelial Cells on Intact and Denuded Human Amniotic Membrane,”Invest. Ophthalmol. Vis. Sci., 41(9):2506-513 (Aug. 2000).
Koizumi, N., et al., “Amniotic Membrane as a Substrate for Cultivating Limbal Corneal Epithelial Cells for Autologous Transplantation in Rabbits,”Cornea, 19(1):65-71 (2000).
Koizumi, N., et al., “An Evaluation of Cultivated Corneal Limbal Epithelial Cells, Using Cell-Suspension Culture,”Invest. Ophthalmol. Vis. Sci., 43 (7): 2114-121 (Jul. 2002).
Gruetrich, M., Tseng,S.C.G., “Human Limbal Progenitor Cells Expanded on Intact Amniotic Membrane Ex Vivo,”Arch Ophthalmol, 120:783-90 (Jun. 2002).
Espana, E., et al., “Human Keratocytes Cultured on Amniotic Membrane Stroma Preserve Morphology and Express Keratocan,”Invest. Ophthalmol. Vis. Sci., 44(12):5136-141 (Dec. 2003).
Koh,S.-W., “VIP Enhances the Differentiation of Retinal Pigment Epithelium in Culture: from cAMP and pp60c-srcto Melanogenesis and Development of Fluid Transport Capacity,”Progress in Retinal and Eye Research, 19(6):669-88 (2000).
Albert, D.M., et al., “In Vitro Growth of Pure Cultures of Retinal Pigment Epithelium,”Arch Ophthalmol, 88: 63-69 (1972).
Binder Susanne
Tseng Scheffer C. G.
Kim Taeyoon
TissueTech, Inc.
Wilson Sonsini Goodrich & Rosati
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