Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1995-07-13
1998-09-01
Weddington, Kevin E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514 3, 514557, 514625, A61K 31195
Patent
active
058011986
ABSTRACT:
Treating mammals having ischemic bowel with a therapeutic quantity of pyruvate enterally or parenterally will retard neutrophil infiltration and retain morphology during and following the bowel ischemia. The pyruvate is introduced into the patient enterally or parenterally during the bowel ischemia or the succeeding bowel reperfusion and, preferably, prior to the bowel ischemia. The pyruvate dosage is from 1% to 20% by weight of the patient's caloric intake.
REFERENCES:
patent: 4158057 (1979-06-01), Stanko
patent: 4351835 (1982-09-01), Stanko
patent: 4415576 (1983-11-01), Stanko
patent: 4548937 (1985-10-01), Stanko
patent: 4812479 (1989-03-01), Stanko
patent: 4874790 (1989-10-01), Stanko
patent: 5134162 (1992-07-01), Stanko
patent: 5256697 (1993-10-01), Miller et al.
patent: 5283260 (1994-02-01), Miller et al.
patent: 5294641 (1994-03-01), Stanko
patent: 5395822 (1995-03-01), Izumi et al.
patent: 5480909 (1996-01-01), Stanko
patent: 5508308 (1996-04-01), Miller et al.
Stanko, et al., Pyruvate Inhibits Clofibrate-Induced Hepatic Peroxisomal Proliferation and Free Radical Production in Rats, Metabolism, vol. 44:2, Feb. 1995, pp. 166-171.
Cicalese, et al., Pyruvate Prevents Ischemia-Reperfusion Mucosal Injury of Rat Small Intestine, The American Journal of Surgery, vol. 171, Jan. 1996, pp. 97-101.
DeBoer, et al., Pyruvate enhanes recovery of rat hearts after ischemia and reperfusion by preventing free radical generation, The American Physiological Society, pp. H1571-H1576.
Rigobello et al., Effect of pyrovate on rat heart thiol status during ischemia acl hypoxia followed by reperfusion. (1993) (see abstract).
Simmonds, N.J. et al., Gastro Enterology 103:186-196, 1992 "Chemiluminescence Assay of Mucosal Reactive Oxygen Metabolites in Inflammatory Bowel Disease".
Borg, D., "Oxygen Free Radicals & Tissue Injury" in Oxygen Free Radicals in Tissue Damage (Tarr et al., eds.) Birkhauser, Boston 1993.
McCamish Mark Anthony
Miller Robert Harold
Stanko Ronald Thomas
Abbott Laboratories
Brainard Thomas D.
Nickey Donald O.
University of Pittsburgh Medical Center
Weddington Kevin E.
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