Retard form of pharmaceuticals with insoluble porous diffusion c

Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...

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424 21, 424 22, 424 32, 424 33, A61K 2712

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active

044592795

ABSTRACT:
A pharmaceutical dosage unit retard form having a constant, pH-independent release rate of active ingredient, consisting of a core comprising an active ingredient, and a semi-permeable diffusion coating over the core, where the coating consists of a water-insoluble film-former, a water-soluble polymer and eventually an acid-insoluble polymer incorporated therein.

REFERENCES:
patent: 2853420 (1958-09-01), Lowey
patent: 2928770 (1960-03-01), Bardani
patent: 2971889 (1961-02-01), Swintosky
patent: 3247066 (1966-04-01), Milosovich
patent: 3344029 (1967-09-01), Berger
patent: 3371015 (1968-02-01), Sjogren et al.
patent: 3538214 (1970-11-01), Polli et al.
patent: 3835221 (1974-09-01), Fulberth et al.
patent: 3917813 (1975-11-01), Pedersen
patent: 4083949 (1978-04-01), Benedickt
patent: 4361546 (1982-11-01), Stricker et al.
Spitael, Pharm. Ind. 39(5): 502-505 (1977) "Factors Affecting the Dissolution Rate of Enteric Coatings".

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