Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell
Patent
1997-03-31
1999-12-14
Naff, David M.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Animal or plant cell
424423, 424426, 424548, 435177, 435180, 435325, 435366, 435375, 435377, 435384, 435395, 435396, 435405, A61K 3532, C12N 1108, C12N 500, C12N 508
Patent
active
060013524
ABSTRACT:
A method for stimulating chondrocyte proliferation and inhibiting chondrocyte differentiation along the endochondral developmental pathway is provided comprising contacting condrocytes with an effective amount of Platelet-Derived Growth Factor (PDGF) such as PDGF-BB, PDGF-AA OR PDGF-AB in the substantial absence of growth factors which promote cell differentiation. This allows such cells to be multiplied in culture for loading onto a scaffolding material and implanting into a cartilage or bone wound.
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Boyan Barbara D.
Schwartz Zvi
Naff David M.
OsteoBiologics, Inc.
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