Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1980-11-12
1983-08-02
Wiseman, Thomas G.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 18, 435 34, 435 91, 435 92, 435803, 435810, C12Q 168, C12Q 134, C12Q 104, C12P 1934
Patent
active
043967132
ABSTRACT:
Hemoflagellates are characterized by restriction endonuclease digestion of the mitochondrial DNA to provide for substantial cleavage of the kDNA network. The resulting electrophoretic profile of the digest can be used as a restriction fingerprint for distinguishing organisms and specific strains. The kDNA is found to be sufficiently stable through numerous passages of the organism to provide a reliable fingerprint.
REFERENCES:
Mattei et al., "Biochemical Strain Characterization of Trypanosoma Cruzi by Restriction Endonuclease Cleavage of Kinetoplast--DNA" FEBS. Letters, vol 74, No. 2 (1977) pp. 264-268.
Borst, et al., "Characterization of DNA from Tyrpanosoma Brucei and Related Trypanosomes by Restriction Endonuclease Digestion", Chem. Abstracts, vol 93, No. 21 (1980), p. 221, Nos. 199423p.
Simpson et al., "Replication and Transcription of Kinetoplast DNA", Chem. Abstracts, vol. 92, No. 17, (1980), p. 275 Abts. No. 143068p.
Riou, et al., "Heterogeneity of the Kinetoplast DNA molecules of Trypanosoma Cruzi", Chem. Absts., vol. 87, No. 5 (1977) p. 120 Absts. No. 34600g.
Brack, et al., "The use of Restriction Endonucleases for the Investigation of Kinetoplast DNA", Chem. Absts. vol. 87, No. 9, (1977), p. 269, Absts. No. 65075u.
Frasch, et al. "The Kinetoplast DNA of Trypanosoma Equiperdum", Biochim. Biophys., Acta, vol. 607 (1980), pp. 397-410.
Williams, et al., "Genomic Rearrangements Correluted with Antigenia Variaton in Trypanosoma Lovercsi" Nature 282 (1979) pp. 847-849.
Mattei, et al. "Biochemical Strain Characterization of Trypanosoma Cruzi, by Restriction Endonuclease Cleavage of Kinetoplast DNA", Chem. Absts., vol. 86 No. 19 (1977) p. 267, Abs. No. 136213(e).
Donelson, et al., "Kinetoplast DNA Minicircles of Trypanosoma Brucei Share Regions of Sequence Homology," Chem. Abstracts, vol. 93 No. 25 (1980) p. 936, Absts. No. 234674v.
Morel Carlos M.
Simpson Larry P.
Rowland Bertram I.
The Regents of the University of Calif.
Wiseman Thomas G.
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