Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-11-14
1999-10-19
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514277, 514337, 514342, 514364, 514461, 514510, 514520, 514535, 514569, 514617, 514621, 514650, 549462, 549467, 549 13, 549356, 549427, 549469, 549470, 546284, 546309, 548183, 558388, 558410, 560 55, 560 59, 560102, 562405, 562466, 562492, 465169, 465180, 568807, 568808, A01N 4304, A01N 4340, C07D30787, C07D40400, C07D27704, C07C25500, C07C 6300, C07C23300
Patent
active
059689080
ABSTRACT:
The invention is novel analogs of 9-cis-retinoic acid which are useful for the treatment and prevention of coronary artery disease and to protect against premature atherosclerosis by increasing HDL levels. The invention includes processes for preparing the novel 9-cis-retinoic acid analogs.
REFERENCES:
Rottman, J. N., et al., Molecular and Cellular Biology, 11, No. 7, 3814-20, 1991.
Gollnick, H., et al., Saurat (ed.) Retinoids: New Treads in Research and Therapy, Retinoid Symposium, Geneva 1984, 445-460 (Kargar, Base 1985).
Zhang, X. et al., Nature, 358, 587-591, 1992.
Jong, L. et al., J. Med. Chem., 36, 2605-2613, 1993.
Birnberg Gary Harold
Epstein Joseph William
Gilbert Adam Matthew
Qing Feng Ling
American Cyanamid Company
Covington Raymond
Kight John
Nagy Michael R.
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