Restorative neuropharmacological agent for motor and speech dist

Details Restorative neuropharmacological agent for motor and speech dist Restorative neuropharmacological agent for motor and speech dist

1994-10-04

1997-08-12

Spivack, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514565, 514614, A61K 31195, A61K 31165

Patent

active

056566697

ABSTRACT:
A restorative neuropharmacological method of treating motor or speech disturbance comprising administration of L- or DL-threo-DOPS or its pharmaceutically acceptable acid-addition-salt to a patient is provided by stimulating the central nervous system so as to enhance intrinsic neuroplasticity and thus increasing functional compensation.

REFERENCES:
patent: 4497826 (1985-02-01), Narabayashi et al.
patent: 4690949 (1987-09-01), Yoshida et al.
Dennis M. Feeny et al, "Amphetamine, Haloperidol, and Experience Interact to Affect Rate of Recovery After Motor Cortex Injury", Science, vol. 217, 27 Aug., 1982, pp. 855-857.
Davis et al, "Amphetamine and Physical Therapy Facilitate Recovery of Function from Stroke: Correlative Animal and Human Studies", Cerebral Diseases, Fifteenth Research (Princeton) Conference, 1987.
Ueno et al., "The Effect of L-threo-DOPS . . . ", Abstracts of 29th Annual Meeting of Japanese Neurological Society, May 25-27, 1988.
Saito et al., "Observation of Remarkable Effect . . . ", Abstracts of 11th Annual Meeting of the Japanese Neurotherapy Society, May 12-13, 1993.
Nishino et al., "1-threo DOPS . . . ", Japanese Journal of Cerebral Blood Flow and Metabolism, vol. 5, No. 1, 1993.
Nishino et al., "Neurobehavioral Study . . . ", Functional Neurosurgery, vol. 30, 1991.
Nishino et al., "Facilitation Effect of . . . ", Abstracts of the 19th Annual Meeting of the Japanese Stroke Society, Mar. 10-11, 1994.

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