Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds hormone or other secreted growth regulatory factor,...
Patent
1996-10-04
1998-12-08
Feisee, Lila
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds hormone or other secreted growth regulatory factor,...
4241301, 4241321, 4241411, 4241431, 4241441, 4241521, 4241721, 5303871, 53038822, 53038823, 53038824, 53038885, 5303892, A61K 39395, C07K 1600, C12P 2108
Patent
active
058465367
ABSTRACT:
A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying .beta..sub.1 integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive.
REFERENCES:
Inhibition of Cell Attachment, Invasion and Mestasis of Human Carcinoma Cells by Anti-integrin B1 Subunit Antibody. Jpn. J. Cancer Research 83, pp. 1317, 1320, 1325, Dec. 1992.
Koretz et al. (1994) Virchows Archiv 425:229-236.
Fujita et al. (1992) Jpn. J. Cancer Res. 83:1317-26.
Amar et al. (1994) J. Neuro-Oncol. 20:1-15.
Pignatelli et al (1992) Br. J. Cancer 66:629-34.
Streuli et al (1991) J. Cell Biol. 115:1383-95.
Dermer, G.B. (1994) Biotechnol. vol. 12: p. 320.
Bissell Mina J.
Weaver Valerie M.
Bansal Geetha P.
Feisee Lila
Martin Paul R.
Ross Pepi
The Regents of the University of California
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