Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Reexamination Certificate
2007-04-17
2007-04-17
Woodward, Michael P. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
C424S486000, C424S484000, C424S400000, C514S772000, C514S772100, C514S772300, C514S772400
Reexamination Certificate
active
10298808
ABSTRACT:
A responsive microgel is provided which responds volumetrically and reversibly to a change in one or more aqueous conditions selected from the group consisting of (temperature, pH, and ionic conditions) comprised of an ionizable network of covalently cross-linked homopolymeric ionizable monomers wherein the ionizable network is covalently attached to an amphiphilic copolymer to form a plurality of ‘dangling chains’ and wherein the ‘dangling chains’ of amphiphilic copolymer form immobile micelle-like aggregates in aqueous solution. A responsive microgel is further provided that comprises at least one therapeutic entity and delivers a substantially linear and sustained release of the therapeutic entity under physiological conditions.
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Bromberg Lev E.
Temchenko Marina
Mathews, Shepherd, McKay & Bruneau, P.A.
Silverman Eric E.
Supratek Pharma Inc.
Woodward Michael P.
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