Response element compositions and assays employing same

Details Response element compositions and assays employing same Response element compositions and assays employing same

2007-03-13

2007-03-13

Ketter, James (Department: 1636)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S325000, C536S024100

Reexamination Certificate

active

10302557

ABSTRACT:
DNA segments have been discovered, and characterized by sequence, which are response elements operative to confer responsiveness to ligands for several members of the steroid/thyroid superfamily of receptors, for the transcriptional activation and/or repression of promoters in cells. By using transcriptional control regions comprising response elements of the present invention in combination with a functional promoter, it is now possible to provide recombinant DNA vectors containing a gene, the transcription (and, thereby, also expression) of which is under the control of a promoter, the transcriptional activity of which is responsive to ligands for members of the steroid/thyroid superfamily of receptors.

REFERENCES:
patent: 5262300 (1993-11-01), Evans et al.
patent: 6281330 (2001-08-01), Evans et al.
patent: WO 88/00975 (1988-02-01), None
patent: WO 91/07488 (1991-05-01), None
Lazar et al., “Thyroid hormone receptors form distinct nuclear protein-dependent and independent complexes with a thyroid hormone response element.” Molecular Endocrinology, 4(11):Nov. 1990, p. 1627-1635.
Munoz-Canoves et al., “Mapping of a retinoic acid-responsive element in the promoter region of the complement factor H gene.” Journal of Biological Chemistry, 265(33):Nov. 25, 1990, p. 20065-20068.
Sucov et al., “Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene.” Proceedings of the National Academy of Sciences USA, 87;Jul. 1990, p. 5392-5396.
Tsai et al., “Molecular Interactions of steroid hormone receptor with its enhancer element: evidence for receptor dimer formation.” Cell, 55:Oct. 1988, p. 361-369.
Vasios et al., “A retinoic acid-responsive element is present in the 5′ flanking region of the laminin Bl gene.” Proceedings of the National Academy of Sciences USA, 86;Dec. 1989, p. 9099-9100.

Affiliated with

Also associated with

Rating

Response element compositions and assays employing same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Response element compositions and assays employing same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Response element compositions and assays employing same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3789937