Resorptive sheet material for closing and healing wounds and met

Details Resorptive sheet material for closing and healing wounds and met Resorptive sheet material for closing and healing wounds and met

1983-04-19

1986-08-19

Rosenbaum, C. Fred

Surgery

Truss

Pad

128325, 128334R, 604358, 604368, 604369, A61L 1500

Patent

active

046063374

ABSTRACT:
A resorptive sheet material for closing and healing wounds substantially consists of a glycoprotein matrix containing substances which cause and, respectively, are conducive to the coagulation of blood including fibrinogen and thrombin. The sheet material is dry and of multi-layered structure, wherein at least one layer is free from thrombin and contains in the glycoprotein matrix thereof the fibrinogen in a substantially homogeneously distributed form, and at least one further layer is free from fibrinogen and contains in the glycoprotein matrix thereof the thrombin in a substantially homogeneously distributed form. The glycoproteins coming into consideration, above all, are non-linked fibrin, fibrin fission products, collagen, globulin, myoglobulin, casein and/or albumin.
Preferably, at least one of the layers, especially one or both outer layer(s), contains fibroblast cells present in dry state and/or agents conducive to the growth of the fibroblasts and their spreading-in, especially chondroitin sulphate.
For the production, fibrinogen is added to a thrombin-free, predominantly aqueous solution and/or suspension of the glycoprotein and said solution and/or suspension is processed to form a sheet-material layer, and onto the full surface of this layer at least one further layer is applied which, in its turn, has been obtained from a further, fibrinogen-free and thrombin-containing solution and/or suspension of the same or of another glycoprotein. In particular, a solution and/or suspension of one composition is applied onto an inert surface, where it is subjected to deep-freezing, and onto the resultant ice-layer surface, when still in the deep-frozen state, a solution and/or suspension of different composition is applied and subjected to deep-freezing, and, finally, all layers are jointly subjected to lyophilization.

REFERENCES:
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patent: 4225580 (1980-09-01), Rothman et al.
patent: 4265233 (1981-05-01), Sugitachi et al.
patent: 4314935 (1982-02-01), Uemura et al.
patent: 4407787 (1983-10-01), Stemberger
patent: 4453939 (1984-06-01), Zimmerman et al.

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