Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1993-12-02
1995-03-14
Foelak, Morton
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
428220, 4283157, 521 64, 521134, 521182, 521189, 525413, 528354, C08J 928, A61F 200, B32B 326
Patent
active
053975723
ABSTRACT:
Resorbable materials and their preparation based on gelling a solution of a single polylactide enantiomer. The gel may be dried to produce solid materials, or may be extracted with a nonsolvent prior to drying to make microporous materials. Physical and mechanical properties of the material may be varied by varying the molecular weight of the gelling polymer, or by blending the gelling solution with other polymers or fillers. The resorbable materials can be used to make biodegradable implantation devices.
REFERENCES:
patent: 4471077 (1984-09-01), Lange
patent: 4550449 (1985-11-01), Tunc
patent: 4563489 (1986-01-01), Urist
patent: 4578384 (1986-03-01), Hollinger
patent: 4637931 (1987-01-01), Schmitz
patent: 4645503 (1987-02-01), Lin et al.
patent: 4719246 (1988-01-01), Murdoch et al.
patent: 4776329 (1988-10-01), Treharne
patent: 4781183 (1988-11-01), Casey e al.
patent: 4792336 (1988-12-01), Hlavacek et al.
patent: 4800219 (1989-01-01), Murdoch et al.
patent: 5290494 (1994-03-01), Coombes et al.
Hollinger, et al., "Biodegradable Bone Repair Materials. Synthetic Polymers and Ceramics", Clin. Orthop. Rel. Resl., No. 207, pp. 290-305 (1986).
Hollinger, "Preliminary report on the osteogenic potential of a biodegradable copolymer of polyactide (PLA) and polyglycolide (PGA)" J. Biomed. Mater. Res., vol. 17, pp. 71-82 (1983).
Higashi, et al., "Polymer-hydroxyapatite composites for biodegradable Bone fillers", Biomaterials, vol. 7, pp. 183-187 (1986).
Schmitz, et al., "A Preliminary Study of the Osteogenic Potential of a Biodegradable Alloplastic-Osteoinductive Alloimplant", Clin. Orthop. Rel. Res., No. 237, pp. 245-255 (1988).
Kulkarni, et al., "Polylactic Acid for Surgical Implants", Arch. Surg., vol. 93, pp. 839-843 (1966).
Getter, et al., "A biodegradable intraosseous appliance in the treatment of mandibular fractures", J. Oral Surg., vol. 30, pp. 344-348 (1972).
Leenslag, et al., "Resorabable materials of poly(L-lactide). VI. Plates and screws for internal fracture fixation", Biomaterials, vol. i, pp. 70-73 (1987).
Bostman, et al., "Biodgradable Internal Fixation For Malleolar Fractures A Prospective Randomised Trail", J. Bone and Joint Surgery, vol. 69-B, No. 4, pp. 615-619 (1987).
Reul, "Use of Vicryl (Polyglactin 910) Sutures in General Surgical and Cardiothoracic Procedures", Ann. J. Surg., vol. 134, pp. 297-299 (1977).
Greisler, "Arterial Regeneration Over Absorbable Prosthesis", Arch. Surg., vol. 117, pp. 1425-1431 (1982).
Schakenraad, et al., "Biodegradable hollow fibres for the controlled release of drugs", Biomaterials, vol. 9, pp. 116-120 (1988).
Goldstrohm, et al., "The Results of 39 Fractures Complicated by Major Segmental Bone Loss and/or Leg Length Discrepancy", J. Trauma, vol. 24 No. 1, pp. 50-58 (1984).
Osborn, et al., "Bonding Osteogensis Induced by Calcium Phosphate Ceramic Implants", Biomaterials, pp. 51-58 (1980).
Holmes, et al., "A Coralline Hydroxyapatite Bone Graft Substitute", Clin. Orthop. Rel. Res., No. 188, pp. 252-262 (1984).
Kelly, et al., "Totally Resorbable High-Strength Composite Materials", Advances in Biomedical Polymers, pp. 75-85 (1987).
Cutright, et al., "The repair of fractures of the orbital floor using biodegradable polylactic acid", Oral Surg., vol. 33, No. 1, pp. 28-34 (1972).
Tunc, et al., "Body Absorbable Osteosynthesis Devices", Advances in Biomedical Polymers, pp. 87-99 (1987).
Christel, et al., "Biodegradable Composites for Internal Fixation" Biomaterials, pp. 271-280 (1980).
Offergeld, et al., "The Injection Molding of Resorbable Implants" ANTEC Abstracts, (1989).
Hollinger et al., "An evaluation of two configurations of tricalcium phosphate or treating craniotomies," J. Biomed. Mater. Res., vol. 23, pp. 17-29.
Boyan Barbara D.
Coombes Allan G. A.
Heckman James D.
Board of Regents , The University of Texas System
Foelak Morton
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