Optics: measuring and testing – By dispersed light spectroscopy – With sample excitation
Patent
1997-01-13
1998-08-11
Font, Frank G.
Optics: measuring and testing
By dispersed light spectroscopy
With sample excitation
356417, 356338, 356339, G01J 330
Patent
active
057934851
ABSTRACT:
A resonant-cavity apparatus for cytometry or particle analysis. The apparatus comprises a resonant optical cavity having an analysis region within the cavity for containing one or more biological cells or dielectric particles to be analyzed. In the presence of a cell or particle, a light beam in the form of spontaneous emission or lasing is generated within the resonant optical cavity and is encoded with information about the cell or particle. An analysis means including a spectrometer and/or a pulse-height analyzer is provided within the apparatus for recovery of the information from the light beam to determine a size, shape, identification or other characteristics about the cells or particles being analyzed. The recovered information can be grouped in a multi-dimensional coordinate space for identification of particular types of cells or particles. In some embodiments of the apparatus, the resonant optical cavity can be formed, at least in part, from a vertical-cavity surface-emitting laser. The apparatus and method are particularly suited to the analysis of biological cells, including blood cells, and can further include processing means for manipulating, sorting, or eradicating cells after analysis thereof.
REFERENCES:
patent: 3916197 (1975-10-01), Fulwyler
patent: 4243318 (1981-01-01), Stohr
patent: 4765737 (1988-08-01), Harris
patent: 4947223 (1990-08-01), Biefeld
patent: 5021661 (1991-06-01), Masutani
patent: 5100627 (1992-03-01), Buican
patent: 5135304 (1992-08-01), Miles
patent: 5138170 (1992-08-01), Noguchi
patent: 5158889 (1992-10-01), Hirako
patent: 5245466 (1993-09-01), Burns
patent: 5296963 (1994-03-01), Murahami
patent: 5322799 (1994-06-01), Miller
patent: 5360739 (1994-11-01), Fan
patent: 5512492 (1996-04-01), Herron
patent: 5583634 (1996-12-01), Andre et al.
Leon Weiss, ed., Histology, 5th edition, chapter 11, pp. 447-473, (Elsevier Biomedical, 1983).
A. Ashkin, J. M. Dziedzic, and T. Yamane, "Optical Trapping and Manipulation of Single Cells Using Infrared Laser Beams," Nature, vol. 330, pp. 769-771, Dec. 1987.
J. K. Foskett and S. Grinstein, eds., Noninvasive Techniques in Cell Biology, chapter 15, pp. 375-402, (John Wiley, 1990).
Y. Kikuchi, K. Sato, H. Ohki, and T. Kaneko, "Optically Accessible Microchannels Formed in Single-Crystal Silicon Substrate for Studies of Blood Rheology," Microvascular Research, vol. 44, pp. 226-240, 1992.
V. V. Tuchin, "Lasers and Fiber Optics in Medicine," Proceedings of the Society of Photoinstrumentation Engineers, vol. 1981, pp. 2-16, 1992.
P. L. Gourley, K. E. Meissner, T. M. Brennan, and B. E. Hammons, "Surface-Emitting Semiconductor Laser Spectroscopy for Characterizing Normal and Sickled Red Blood Cells," Proceedings of the Society of Photoinstrumentation Engineers, vol. 2387, pp. 148-160. Mar. 1995.
K. E. Meissner, P. L. Gourley, T. M. Brennan, B. E. Hammons, and A. E. McDonald, "Surface-Emitting Semiconductor Laser for Intracavity Spectroscopy and Microscopy," Proceedings of the Society of Photoinstrumentation Engineers, vol. 2399, pp. 561-570, Jul. 1995.
P. L. Gourley, K. E. Meissner, M. F. Gourley and J. Lyo, "A Radically New Approach to Cell-Structure Analysis," Biophotonics International, pp. 48-56, Jul./Aug. 1995.
P. L. Gourley, A. E. McDonald, and M. F. Gourley, "Vertical Cavity Surface-Emitting Laser Scanning Cytometer for High Speed Analysis of Cells," Proceedings of the Society of Photoinstrumentation Engineers, vol. 2679, pp. 131-141, Jan. 29-30, 1996.
P. L. Gourley, M. F. Gourley, T. Bloclage, and M. Luke, "Vertical Cavity Surface-Emitting Laser Cytometer for Analysis of Cells," Presented at the 1996 Conference on Lasers and Electro-Optics (CLEO), Anaheim, CA, May 22-27 1996.
P. L. Gourley and M. F. Gourley, "A Biological Microcavity Laser," Presented at the International Quantum Electronics Conference (IEEE), Sidney, Australia, Jul. 14-19, 1996.
P. L. Gourley, "Semiconductor Microlasers: A New Approach to Cell-Structure Analysis," Nature Medicine, vol. 2, pp. 942-944, Aug. 1996.
K. E. Meissner, P. L. Gourley, T. M. Brennan, B. E. Hammons, and A. E. McDonald, "Intracavity Spectroscopy in Vertical Cavity Surface-Emitting Lasers for Micro-Optical-Mechanical Systems," Applied Physics Letters, vol. 69, pp. 1517-1519, 9 Sep. 1996.
Font Frank G.
Hohimer John P.
Ratliff Reginald A.
Sandia Corporation
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