Resonance raman spectroscopy for identifying and quantitating bi

Optics: measuring and testing – By dispersed light spectroscopy – With raman type light scattering

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356302, 356303, 356319, 356326, 356327, G01J 344

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060409061

ABSTRACT:
The invention uses a resonance Raman spectrometer 1 for achieving the identification and quantitation of analytes including biomolecules, organic and inorganic molecules. According to the present invention, a) a sample 2 is deuterated 3 with D20 for facilitating identification and quantitation of analytes 4 of said sample, b) a monochromatic light 6 illuminates sample 2 of analytes 4 for producing Raman sample light 12 and rejecting Rayleigh light 14, c) the Raman sample light 12 is passed through a depolarizer 19 for producing randomized polarization components 20, d) a Raman sample spectrum 22 is generated, calibrated with respect to an absolute differential Raman cross-section standard in response to said randomized polarization components 22, e) the Raman sample spectrum 22 is provided to a spectral analyzer 24 for identification 26 and/or quantitation 28 of the analytes 4.

REFERENCES:
patent: 4847198 (1989-07-01), Nelson et al.
patent: 4884886 (1989-12-01), Salzman et al.
Asher, S. A., C. R. Johnson and J. Murtaugh (1983). "Development of a New UV Resonance Raman Spectrometer for the 217-400-NM Spectral Region." Rev. Sci. Instrum. 54(12): 1657-62. Summarizes State of RRS as of 1983.
Benevides, J. M. and G. Thomas Jr., J. (1985). "Dependence of Purine 8C-H Exchange on Nucleic Acid Conformation and Base-Paring Geometry: A Dynamic Probe of DNA and RNA Secondary Structures*." Biopolymers 24: 667-682. Relates to Hyrdogen Exchange.
Bird, G. R. and W. A. Shurcliff (1959). "Pile-of-Plates Polarizers for the Infrared: Improvement in Analysis and Design." Journal of Optical Society of America 49(3): 235-37.Discusses Plate Polarizers.
Dudik, J. M., C. R. Johnson and S. A. Asher (1985). "Wavelength Dependence of the Preresonance Raman Cross Sections of Acetonitrile, Sulfate Ion, Perchlorate Ion and Nitrate Ion." J. Chem. Phys. 82(4): 1732-40. Dicusses Raman Cross Sections.
Englander, S. W. and N. R. Kallenbach (1984). "Hydrogen Exchange and Structural Dynamics of Proteins and Nucleic Acids." Quarterly Review of Biophysics 16(4): 521-655. Discusses Hydrogen Exchange.
Englander, S. W. and L. Mayne (1992). "Protein Folding Studied Using Hydrogen-Exchange Labeling and Two-Dimentional NMR." Annual Reviews in Biophysics and Biomolecular Structure 21: 243-65. Discusses Hydrogen Exchange with Proteins.
Harhay, G. P. (1992). Ultraviolet Resonance Raman Spectroscopy Of The Tertiary Peptide Bond. Department of Chemistry. Eugene, Or, University of Oregon: 229. Both invention and the reference discuss RRS.
Hudson, B. and L. Mayne (1986). Ultraviolet Resonance Raman Spectroscopy of Biopolymers. Methods Enzymol. 130: 331-50. Change in Raman Spectrum.
Hudson, B. and L. C. Mayne (1987). Peptides and Protein Sides Chains. Biological Applications of Raman Spectroscopy: Resonance Raman Spectra of Polyenes and Aromatics. T. G. Spiro. New York, Wiley. 2: 181-209.
Klawun, C. and C. L. Wilkins (1995). "Neural-Network Assisted Rapid Screening Of Large Infrared Spectral Databases." Analytical Chemistry 67(2): 374-378. Neural Nets as They Might Relate to Invention's Use of Spectral Libraries.
Korenowski, G. M., L. D. Ziegler and A. C. Albrecht (1978). "Calculations of Resonance Raman Cross Section in Forbidden Electronic Transitions: Scattering of the 992 CM-1 Mode in the 1B2U Band of Benzene." J. Chem. Phys. 68(3): 1248-52. Relates to Raman Cross Sections.
Kubasek, W. L., B. Hudson and W. L. Peticolas (1985). "Ultraviolet Resonance Raman Excitation Profiles of Nucleic Acid Bases with Excitation From 200 to 300 Nanometers." Proc. Natl. Acad. Sci. U.S.A. 82(8): 2369-73. pH Dependence of Raman Spectra.
Li, B. and A. B. Myers (1990). "Absolute Raman Cross Sections for Cyclohexane, Acetonitrile, and Water in the Far-Ultraviolet Region." J. Phys. Chem. 94(10): 4051-4. Discusses Raman Cross Section Standards.
Mayne, L. C., L. D. Ziegler and B. Hudson (1985). "Ultraviolet Resonance Raman Studies of N-Methylacetamide." J. Phys. Chem. 89(15): 3395-8. Change in Solvent on RRS.
Myers, A. B. (1991). "Resonance Raman Depolarization Ratios as a Probe of Ultrafast Excited-State Torsional Dynamics: A Critical Evaluation." J. Phys. Chem. 95(4): 1536-8.Relates to Raman Cross Sections and Their Depolarization Ratios.
Myers, A. B. and R. A. Mathies (1987). Resonance Raman Intensities: A Probe of Excited-State Structure and Dynamics. Biological Applications of Resonance Raman Spectroscopy. T.G. Spiro. New York, Wiley. 2: 1-58. Spectrometer Independent Spectroscopy.
Nelson, W. H., R. A. Dalterio and S. Peacedale (1989). Detection and Identification of Bacteria by Means of Ultra-Violet Excited Resonance Raman Spectra. PTO. USA, The Board of Governors for Higher Education, State of Rhode Island and Providence Plantations. RRS Done on Bacteria.
Nelson, W. H., R. Manoharan and J. F. Sperry (1991). "UV Resonance Raman Studies of Bacteria." Appl. Spectrosc. Rev. 27(1): 67-124. RRS Done on Bacteria.
Salzman, G. C., C. T. Gregg, W. K. Grace and R. D. Hiebert (1989). Biological Particle Identification. PTO. USA, The United States of America as Represented by the Department of Energy, Relates to Bacterial Identification.
Schomacker, K. T., J. K. Delaney and P. M. Champion (1986). "Measurements of the Absolute Raman Cross Sections of Benzene." Journal of Chemical Physics 85(8): 4240-47. Discusses Local Field Correction.
Schulze, H. G., M. W. Blades, A. V. Bree, B. B. Gorzalka, L. S. Greek and R. F. B. Turner (1994). "Characteristics of Backpropagation Neural Networks Employed in the Identification of Neurotransmitter Raman-Spectra." Applied Spectroscopy 48(1): 50-57. Relates to Raman Spectra and Their Uses with Neural Nets.
Sension, R. J. and H. L. Strauss (1986). "Comparison of Experiment and Theory for the Resonance Raman Excitation Profile of Diatomic Iodine in N-Hexine." J. Chem. Phys. 85(7): 3791-806. Depolarization Ratio Changes with Excitation Frequency.
Siebrand, W. and M. Z. Zgierski (1982). "Effect of Solvent-Induced Line Broadening on Resonance Raman Excitation Profiles and Depolarization Ratios." J. Phys. Chem. 86(24): 4718-25. Why Depolarization Ratio Changes with Excitation Frequency.
Siragusa, G. R., C. N. Cutter, W. J. Dorsa, and M. Koohmaraie (1995). "Use of a Rapid Microbial ATP Bioluminescence Assay to Detect Contamination on Beef and Pork Carcasses." J. Food Prot. 58: 770-775. Discusses Sample Prep of a Beef Menstrua Solution.
Smith, S. O., M. S. Braiman, A. B. Myers, J. A. Pardoen, J. M. L. Courtin, C. Winkel, J. Lugtenburg and R. A. Mathies (1987). "Vibrational Analysis of the All-Trans-Retinal Chromophore in Light-Adapted Bacteriorhodopsin." J. Am. Chem. Soc. 109(10): 3108-25. Relates to RRS Done on Bacteriarhodopsin.
Tanabe, K., T. Tamura and H. Uesaka (1992). "Neural Network System for the Identification of Infrared Spectra." Applied Spectroscopy 46(5): 807-10. Relates to Patent Appliction's Discussion of Neural Nets for Bacterial Identification.
Womack, J. D., C. K. Mann and T. G. Vickers (1989). "Correction for Absorption in Raman Measurements Using the Backscattering Geometry." Applied Spectroscopy 43(3): 527-31. Relates to Self-Absorption Correction.
Ziegler, L. D., B. Hudson, D. P. Strommen and W. L. Peticolas (1984). "Resonance Raman Spectra of Mononucleotides Obtained with 266 and 213 NM Ultraviolet Radiation." Biopolymers 23(10): 2067-81. Discusses excitation frequency effects on RRS of DNA and RNA and mononucleotides.

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