Resolution process for benzazepine intermediates

Details Resolution process for benzazepine intermediates Resolution process for benzazepine intermediates

1988-11-23

1989-12-05

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D22316

Patent

active

048853640

ABSTRACT:
In accordance with the present invention an improved process for preparing resolved compounds of the formula ##STR1## being the cis(+) isomer, is disclosed, wherein R.sub.1 and R.sub.2 are each independently hydrogen, halogen, alkyl, alkoxy, aryloxy, arylalkoxy, diarylalkoxy, arylalkyl, cyano, hydroxy, alkanoyloxy, ##STR2## fluoro substituted alkoxy, fluoro substituted alkyl, (cycloalkyl)alkoxy --NO.sub.2, NX.sub.3 X.sub.4, --S(O).sub.m alkyl, ##STR3## m is 0, 1 or 2; X.sub.1 and X.sub.2 are each independently hydrogen, alkyl, aryl or heteroaryl, or X.sub.1 and X.sub.2 together with the nitrogen atom to which they are attached are pyrrolidinyl, piperidinyl or morpholinyl;

REFERENCES:
patent: 4748239 (1988-05-01), Floyd et al.
P. Newman, "Optical Resolution Procedures for Chemical Compounds", vol. 3, pp. 15, 112, 115, 120-122, 163, 175, 231 (1984).

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